Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4773149..4773809 Replicon chromosome
Accession NZ_CP058671
Organism Salmonella enterica strain MS114

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag HWV51_RS23150 Protein ID WP_000244756.1
Coordinates 4773396..4773809 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag HWV51_RS23145 Protein ID WP_000351186.1
Coordinates 4773149..4773415 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV51_RS23125 (4769078) 4769078..4770511 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
HWV51_RS23130 (4770669) 4770669..4770980 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
HWV51_RS23135 (4771144) 4771144..4771803 + 660 WP_000250285.1 hemolysin III family protein -
HWV51_RS23140 (4771919) 4771919..4772899 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
HWV51_RS23145 (4773149) 4773149..4773415 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
HWV51_RS23150 (4773396) 4773396..4773809 + 414 WP_000244756.1 protein YgfX Toxin
HWV51_RS23155 (4773862) 4773862..4774383 - 522 WP_001055885.1 flavodoxin FldB -
HWV51_RS23160 (4774496) 4774496..4775392 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
HWV51_RS23165 (4775416) 4775416..4776129 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HWV51_RS23170 (4776135) 4776135..4777868 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T167132 WP_000244756.1 NZ_CP058671:4773396-4773809 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T167132 NZ_CP074699:2417-2704 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT167132 WP_000351186.1 NZ_CP058671:4773149-4773415 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167132 NZ_CP074699:2691-3005 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References