Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3423498..3424279 Replicon chromosome
Accession NZ_CP058671
Organism Salmonella enterica strain MS114

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3V9S3T1
Locus tag HWV51_RS16715 Protein ID WP_000625910.1
Coordinates 3423498..3423989 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag HWV51_RS16720 Protein ID WP_001110453.1
Coordinates 3423986..3424279 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV51_RS16690 (3418634) 3418634..3421072 - 2439 WP_001014137.1 F4 (K88) fimbrial usher FaeD -
HWV51_RS16695 (3421082) 3421082..3421621 - 540 WP_000721295.1 type 1 fimbrial protein -
HWV51_RS16700 (3421656) 3421656..3421946 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
HWV51_RS16705 (3422533) 3422533..3422790 + 258 WP_001112993.1 hypothetical protein -
HWV51_RS16710 (3423035) 3423035..3423283 - 249 Protein_3267 IS481 family transposase -
HWV51_RS16715 (3423498) 3423498..3423989 - 492 WP_000625910.1 GNAT family N-acetyltransferase Toxin
HWV51_RS16720 (3423986) 3423986..3424279 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
HWV51_RS16725 (3424597) 3424597..3424818 + 222 WP_031617221.1 hypothetical protein -
HWV51_RS16730 (3425082) 3425082..3425957 + 876 WP_000921674.1 AraC family transcriptional regulator -
HWV51_RS16735 (3425954) 3425954..3426241 + 288 WP_001269916.1 transcriptional regulator RtsB -
HWV51_RS16740 (3426234) 3426234..3426416 - 183 WP_024133183.1 ATP-binding cassette domain-containing protein -
HWV51_RS16745 (3426454) 3426454..3426534 + 81 Protein_3274 hypothetical protein -
HWV51_RS16750 (3426644) 3426644..3426778 + 135 Protein_3275 hypothetical protein -
HWV51_RS16755 (3427073) 3427073..3427978 - 906 WP_001268257.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 3409305..3426560 17255


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.51 Da        Isoelectric Point: 7.7297

>T167129 WP_000625910.1 NZ_CP058671:c3423989-3423498 [Salmonella enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQITGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T167129 NZ_CP074696:4200-4487 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT167129 WP_001110453.1 NZ_CP058671:c3424279-3423986 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT167129 NZ_CP074696:4474-4788 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9S3T1

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References