Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2582141..2582761 Replicon chromosome
Accession NZ_CP058671
Organism Salmonella enterica strain MS114

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HWV51_RS12715 Protein ID WP_001280991.1
Coordinates 2582543..2582761 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag HWV51_RS12710 Protein ID WP_000344807.1
Coordinates 2582141..2582515 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV51_RS12700 (2577280) 2577280..2578473 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HWV51_RS12705 (2578496) 2578496..2581645 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
HWV51_RS12710 (2582141) 2582141..2582515 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
HWV51_RS12715 (2582543) 2582543..2582761 + 219 WP_001280991.1 HHA domain-containing protein Toxin
HWV51_RS12720 (2582940) 2582940..2583491 + 552 WP_001278788.1 maltose O-acetyltransferase -
HWV51_RS12725 (2583607) 2583607..2584077 + 471 WP_000136183.1 YlaC family protein -
HWV51_RS12730 (2584133) 2584133..2584273 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
HWV51_RS12735 (2584279) 2584279..2584539 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
HWV51_RS12740 (2584764) 2584764..2586314 + 1551 WP_000213144.1 EAL domain-containing protein -
HWV51_RS12750 (2586545) 2586545..2586934 + 390 WP_000961285.1 MGMT family protein -
HWV51_RS12755 (2586967) 2586967..2587536 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T167120 WP_001280991.1 NZ_CP058671:2582543-2582761 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167120 NZ_CP074681:136164-136580 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT167120 WP_000344807.1 NZ_CP058671:2582141-2582515 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT167120 NZ_CP074681:135937-136167 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References