167110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 249660..250327 Replicon chromosome
Accession NZ_CP058671
Organism Salmonella enterica strain MS114

Toxin (Protein)


Gene name ypjF Uniprot ID A0A3V9RYJ5
Locus tag HWV51_RS01215 Protein ID WP_023139840.1
Coordinates 249660..249989 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A3V9RY53
Locus tag HWV51_RS01220 Protein ID WP_000065828.1
Coordinates 250010..250327 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV51_RS01195 (246172) 246172..246744 - 573 WP_000190912.1 flagellar phase variation DNA invertase Hin -
HWV51_RS01200 (246836) 246836..248338 + 1503 WP_000079789.1 FliC/FljB family flagellin -
HWV51_RS01205 (248406) 248406..248945 + 540 WP_000388869.1 phase 1 flagellin gene repressor FljA -
HWV51_RS01210 (248973) 248973..249195 + 223 Protein_234 helix-turn-helix domain-containing protein -
HWV51_RS01215 (249660) 249660..249989 - 330 WP_023139840.1 TA system toxin CbtA family protein Toxin
HWV51_RS01220 (250010) 250010..250327 - 318 WP_000065828.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HWV51_RS01225 (250346) 250346..250567 - 222 WP_000691990.1 DUF987 domain-containing protein -
HWV51_RS01230 (250576) 250576..251058 - 483 WP_001518223.1 DNA repair protein RadC -
HWV51_RS01235 (251067) 251067..251525 - 459 WP_000155322.1 antirestriction protein -
HWV51_RS01240 (251611) 251611..251829 - 219 WP_031225670.1 DUF905 domain-containing protein -
HWV51_RS01245 (251836) 251836..252069 - 234 Protein_241 50S ribosome-binding GTPase -
HWV51_RS01250 (252328) 252328..254391 + 2064 WP_223229025.1 NERD domain-containing protein kinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - luxS / mig-14 / pipB2 / iroN / iroD / iroC / iroB 178286..268585 90299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12271.23 Da        Isoelectric Point: 9.4828

>T167110 WP_023139840.1 NZ_CP058671:c249989-249660 [Salmonella enterica]
MKTLPATISRATKPCLSPVAVWQMLLTRLLDQHYGLTLNDTPFSDKTVIQEYINAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQSPYLSVVDILQARRSTGLLKTDVK

Download         Length: 330 bp

>T167110 NZ_CP074680:3772726-3773004 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11913.44 Da        Isoelectric Point: 6.6246

>AT167110 WP_000065828.1 NZ_CP058671:c250327-250010 [Salmonella enterica]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECRRLDETFPHFISQMESMLTTGEMNPRHAHCVILYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT167110 NZ_CP074680:3772463-3772723 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9RYJ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9RY53

References