Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 112253..113067 Replicon chromosome
Accession NZ_CP058671
Organism Salmonella enterica strain MS114

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3V9S344
Locus tag HWV51_RS00515 Protein ID WP_000971652.1
Coordinates 112253..112780 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag HWV51_RS00520 Protein ID WP_000855694.1
Coordinates 112777..113067 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV51_RS00485 (108456) 108456..108854 + 399 Protein_94 cytoplasmic protein -
HWV51_RS00490 (109065) 109065..109283 + 219 Protein_95 hypothetical protein -
HWV51_RS00495 (109440) 109440..110108 + 669 WP_000445911.1 hypothetical protein -
HWV51_RS00500 (110135) 110135..110629 + 495 WP_000424941.1 hypothetical protein -
HWV51_RS00505 (110874) 110874..111530 - 657 WP_000420454.1 protein-serine/threonine phosphatase -
HWV51_RS00510 (111757) 111757..112180 + 424 Protein_99 transposase -
HWV51_RS00515 (112253) 112253..112780 - 528 WP_000971652.1 GNAT family N-acetyltransferase Toxin
HWV51_RS00520 (112777) 112777..113067 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
HWV51_RS00525 (113661) 113661..113987 + 327 WP_000393298.1 hypothetical protein -
HWV51_RS00530 (114259) 114259..114606 - 348 WP_001555786.1 DUF1493 family protein -
HWV51_RS00535 (114591) 114591..115040 - 450 WP_000381618.1 hypothetical protein -
HWV51_RS00540 (115472) 115472..115915 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
HWV51_RS00545 (116372) 116372..117022 + 651 WP_023166786.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 112040..112180 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19041.94 Da        Isoelectric Point: 9.8881

>T167109 WP_000971652.1 NZ_CP058671:c112780-112253 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLKDQPLSLLL
SFKTLYAALAASGRL

Download         Length: 528 bp

>T167109 NZ_CP074680:3545086-3545628 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT167109 WP_000855694.1 NZ_CP058671:c113067-112777 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT167109 NZ_CP074680:3544791-3545102 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9S344

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References