Detailed information of TA system TA167108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 2441694..2442353
• Replicon: chromosome
• Accession: NZ_CP058670
• Organism: Chryseoglobus indicus strain CTD02-10-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HUJ41_RS11915
• Protein ID: WP_179872719.1
• Coordinates: 2441961..2442353 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUJ41_RS11910
• Protein ID: WP_179872718.1
• Coordinates: 2441694..2441957 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUJ41_RS11870	2436877..2437731	+	855	WP_179872712.1	DUF4097 family beta strand repeat protein	-
HUJ41_RS11875	2437728..2438402	+	675	WP_179872713.1	PadR family transcriptional regulator	-
HUJ41_RS11880	2438409..2439065	-	657	WP_179872714.1	hypothetical protein	-
HUJ41_RS11885	2439149..2439589	+	441	WP_179872715.1	CrcB family protein	-
HUJ41_RS11890	2439605..2439955	+	351	WP_179874015.1	fluoride efflux transporter CrcB	-
HUJ41_RS11895	2439944..2440117	-	174	WP_179872716.1	hypothetical protein	-
HUJ41_RS11900	2440120..2441223	-	1104	WP_179872717.1	NAD(P)/FAD-dependent oxidoreductase	-
HUJ41_RS11905	2441385..2441576	+	192	WP_152583838.1	DUF3073 domain-containing protein	-
HUJ41_RS11910	2441694..2441957	+	264	WP_179872718.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HUJ41_RS11915	2441961..2442353	+	393	WP_179872719.1	type II toxin-antitoxin system VapC family toxin	Toxin
HUJ41_RS11920	2442371..2443465	-	1095	WP_179872720.1	phosphoribosylformylglycinamidine cyclo-ligase	-
HUJ41_RS11925	2443539..2444996	+	1458	WP_179872721.1	amidophosphoribosyltransferase	-
HUJ41_RS11930	2444993..2445373	-	381	WP_179872722.1	hypothetical protein	-
HUJ41_RS11935	2445409..2445801	-	393	WP_179872723.1	hypothetical protein	-
HUJ41_RS11940	2445852..2447105	+	1254	WP_179872724.1	phosphoribosylamine--glycine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-51)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13866.86 Da
• Isoelectric Point: 4.9344

>T167108 WP_179872719.1 NZ_CP058670:2441961-2442353 [Chryseoglobus indicus]
VALYFDTSALVKLVVAEPETTALRDAARVSTVEPVSSDLTRTELLRTVRRGAPDRLVSAREVLEALTLVPVTTEVCEAAG
RLEPRTLRALDALHLASALGLGDDLEAVVTYDHRLADACRANGVAVLAPH

Nucleotide

• Length: 393 bp

>T167108 NZ_CP074680:3509676-3509894 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9163.45 Da
• Isoelectric Point: 8.7502

>AT167108 WP_179872718.1 NZ_CP058670:2441694-2441957 [Chryseoglobus indicus]
MAEVGIRALKQNASAVVADAAAGETVTITDRGRPVAQLTSIAASPLQRMLANGTARRARRDLASLPAPTEAPPLTPVLAE
IRDDERY

Nucleotide

• Length: 264 bp

>AT167108 NZ_CP074680:3509276-3509650 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG