Detailed information of TA system TA167107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK(toxin)
• Location: 1032339..1032952
• Replicon: chromosome
• Accession: NZ_CP058670
• Organism: Chryseoglobus indicus strain CTD02-10-2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HUJ41_RS05050
• Protein ID: WP_179873880.1
• Coordinates: 1032608..1032952 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HUJ41_RS05045
• Protein ID: WP_179873611.1
• Coordinates: 1032339..1032614 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUJ41_RS05020	1029471..1029779	+	309	WP_152583138.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HUJ41_RS05025	1029769..1030068	+	300	WP_152583106.1	putative addiction module antidote protein	-
HUJ41_RS05030	1030155..1030418	+	264	WP_152583105.1	ribbon-helix-helix protein, CopG family	-
HUJ41_RS05035	1030456..1031769	+	1314	WP_179873609.1	plasmid pRiA4b ORF-3 family protein	-
HUJ41_RS05040	1031877..1032305	+	429	WP_179873610.1	hypothetical protein	-
HUJ41_RS05045	1032339..1032614	+	276	WP_179873611.1	hypothetical protein	Antitoxin
HUJ41_RS05050	1032608..1032952	+	345	WP_179873880.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HUJ41_RS05055	1032942..1033343	-	402	WP_152583100.1	DUF1622 domain-containing protein	-
HUJ41_RS05060	1033367..1034317	-	951	WP_179873881.1	IS481 family transposase	-
HUJ41_RS05065	1034382..1035590	+	1209	WP_179873612.1	IS21 family transposase	-
HUJ41_RS05070	1035590..1036390	+	801	WP_152584343.1	IS21-like element helper ATPase IstB	-
HUJ41_RS05075	1036758..1036955	-	198	Protein_996	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1030783..1061839	31056
	-	flank	IS/Tn	-	-	1037016..1037339	323

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-114)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12122.04 Da
• Isoelectric Point: 8.0510

>T167107 WP_179873880.1 NZ_CP058670:1032608-1032952 [Chryseoglobus indicus]
MVIARGDVCWVDLGPIVDRGPAKHRPVVIVQSDDYTRSRLGTVVVAAISSSTARAGIPGNVFVPTSASGLPKDSVVIATE
VLTLDRDHIGEPIGRLPTPLMREIDSGLRRVLSL

Nucleotide

• Length: 345 bp

>T167107 NZ_CP074680:2673897-2674004 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10315.36 Da
• Isoelectric Point: 4.4687

>AT167107 WP_179873611.1 NZ_CP058670:1032339-1032614 [Chryseoglobus indicus]
MKTAISVPDPLFEKVERARPDLGMSRSQFYATAAKHYLDSVEREALTSEIDAALQTVRGDSHAQAAEEHERADLSQQSLR
RLELLTEDDDW

Nucleotide

• Length: 276 bp

>AT167107 NZ_CP074680:c2673847-2673784 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT