Detailed information of TA system TA167102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2185915..2186465
• Replicon: chromosome
• Accession: NZ_CP058668
• Organism: Treponema sp. B152

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M2RQG8
• Locus tag: HYB91_RS10310
• Protein ID: WP_002676862.1
• Coordinates: 2186184..2186465 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QD7
• Locus tag: HYB91_RS10305
• Protein ID: WP_002665927.1
• Coordinates: 2185915..2186187 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYB91_RS10270 (HYB91_10250)	2181896..2182219	+	324	WP_002676874.1	hypothetical protein	-
HYB91_RS10275 (HYB91_10255)	2182318..2183112	+	795	WP_002676872.1	DUF4261 domain-containing protein	-
HYB91_RS10280 (HYB91_10260)	2183190..2183348	+	159	WP_010956759.1	hypothetical protein	-
HYB91_RS10285 (HYB91_10265)	2183551..2184219	+	669	WP_002676867.1	hypothetical protein	-
HYB91_RS10290 (HYB91_10270)	2184259..2184828	+	570	WP_002676866.1	hypothetical protein	-
HYB91_RS10295 (HYB91_10275)	2184873..2185589	+	717	WP_002676864.1	hypothetical protein	-
HYB91_RS10300 (HYB91_10280)	2185640..2185849	+	210	WP_080612184.1	hypothetical protein	-
HYB91_RS10305 (HYB91_10285)	2185915..2186187	+	273	WP_002665927.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HYB91_RS10310 (HYB91_10290)	2186184..2186465	+	282	WP_002676862.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HYB91_RS10315 (HYB91_10295)	2186539..2187162	+	624	WP_245522439.1	hypothetical protein	-
HYB91_RS10320 (HYB91_10300)	2187200..2188051	+	852	WP_002676859.1	DUF2262 domain-containing protein	-
HYB91_RS10325 (HYB91_10305)	2188073..2189137	+	1065	WP_002676858.1	ankyrin repeat domain-containing protein	-
HYB91_RS10330 (HYB91_10310)	2189319..2190446	+	1128	WP_002672589.1	hypothetical protein	-
HYB91_RS10335 (HYB91_10315)	2190563..2190940	+	378	WP_252508182.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11083.96 Da
• Isoelectric Point: 9.8023

>T167102 WP_002676862.1 NZ_CP058668:2186184-2186465 [Treponema sp. B152]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGARECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T167102 NZ_CP074680:2063536-2063639 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10205.78 Da
• Isoelectric Point: 5.1486

>AT167102 WP_002665927.1 NZ_CP058668:2185915-2186187 [Treponema sp. B152]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT167102 NZ_CP074680:c2063677-2063406 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: M2RQG8

Antitoxin

• AlphaFold DB: Q73QD7