Detailed information of TA system TA167101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-DinJ
• Location: 2047408..2047933
• Replicon: chromosome
• Accession: NZ_CP058668
• Organism: Treponema sp. B152

Toxin (Protein)

• Gene name: relB
• Uniprot ID: M2SKE4
• Locus tag: HYB91_RS09560
• Protein ID: WP_002677039.1
• Coordinates: 2047670..2047933 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73PY2
• Locus tag: HYB91_RS09555
• Protein ID: WP_002677040.1
• Coordinates: 2047408..2047665 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYB91_RS09550 (HYB91_09515)	2045807..2047075	-	1269	WP_002677041.1	OmpA family protein	-
HYB91_RS09555 (HYB91_09520)	2047408..2047665	+	258	WP_002677040.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HYB91_RS09560 (HYB91_09525)	2047670..2047933	+	264	WP_002677039.1	Txe/YoeB family addiction module toxin	Toxin
HYB91_RS09565 (HYB91_09530)	2048048..2048326	+	279	WP_002677038.1	hypothetical protein	-
HYB91_RS09570 (HYB91_09535)	2048310..2048717	+	408	WP_002677037.1	type II toxin-antitoxin system VapC family toxin	-
HYB91_RS09575 (HYB91_09540)	2049099..2049314	+	216	WP_002672335.1	hypothetical protein	-
HYB91_RS09580 (HYB91_09545)	2049311..2049706	+	396	WP_002672336.1	PIN domain-containing protein	-
HYB91_RS09585 (HYB91_09550)	2049760..2050665	+	906	WP_002677034.1	YafY family protein	-
HYB91_RS09590 (HYB91_09555)	2050742..2051254	+	513	WP_002677032.1	ClbS/DfsB family four-helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-63)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10419.98 Da
• Isoelectric Point: 9.7704

>T167101 WP_002677039.1 NZ_CP058668:2047670-2047933 [Treponema sp. B152]
MIKAWDEDAWIDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKGNLSGFWSRRIDKKNRLVYRIVDNVIQIIQC
RTHYGEK

Nucleotide

• Length: 264 bp

>T167101 NZ_CP074680:1856665-1856919 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.39 Da
• Isoelectric Point: 9.5364

>AT167101 WP_002677040.1 NZ_CP058668:2047408-2047665 [Treponema sp. B152]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDIVE

Nucleotide

• Length: 258 bp

>AT167101 NZ_CP074680:1856417-1856668 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: M2SKE4

Antitoxin

• AlphaFold DB: Q73PY2