Detailed information of TA system TA167099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 586595..587180
• Replicon: chromosome
• Accession: NZ_CP058668
• Organism: Treponema sp. B152

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: E9S222
• Locus tag: HYB91_RS02640
• Protein ID: WP_002668014.1
• Coordinates: 586923..587180 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q73KK4
• Locus tag: HYB91_RS02635
• Protein ID: WP_002668012.1
• Coordinates: 586595..586930 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYB91_RS02620 (HYB91_02620)	582055..583266	+	1212	WP_002668007.1	substrate-binding domain-containing protein	-
HYB91_RS02625 (HYB91_02625)	583377..584870	+	1494	WP_253719611.1	sugar ABC transporter ATP-binding protein	-
HYB91_RS02630 (HYB91_02630)	584895..586589	+	1695	WP_253719612.1	galactoside ABC transporter permease	-
HYB91_RS02635 (HYB91_02635)	586595..586930	-	336	WP_002668012.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HYB91_RS02640 (HYB91_02640)	586923..587180	-	258	WP_002668014.1	type II toxin-antitoxin system HicA family toxin	Toxin
HYB91_RS02645 (HYB91_02645)	587349..588548	+	1200	WP_002675658.1	galactokinase	-
HYB91_RS02650 (HYB91_02650)	588714..589313	+	600	WP_002675657.1	hypothetical protein	-
HYB91_RS02655 (HYB91_02655)	589329..590636	+	1308	WP_002688510.1	right-handed parallel beta-helix repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-82)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9589.93 Da
• Isoelectric Point: 10.6118

>T167099 WP_002668014.1 NZ_CP058668:c587180-586923 [Treponema sp. B152]
VNTKNKKTLENIYKRPVPADIFWTDIESLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKITDKGAVNSVRRFLENA
GVKND

Nucleotide

• Length: 258 bp

>T167099 NZ_CP074680:1334150-1334548 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12628.35 Da
• Isoelectric Point: 4.9348

>AT167099 WP_002668012.1 NZ_CP058668:c586930-586595 [Treponema sp. B152]
MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFIDSVDDYINWCREENIEPEKPYSGKFNIRISPELH
KKIAINAKSLNLSLNTFVEKALQHELASTGI

Nucleotide

• Length: 336 bp

>AT167099 NZ_CP074680:1333923-1334150 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Toxin

• AlphaFold DB: E9S222

Antitoxin

• AlphaFold DB: Q73KK4