Detailed information of TA system TA167095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 350002..350614
• Replicon: chromosome
• Accession: NZ_CP058666
• Organism: Streptococcus agalactiae strain S9968

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: S9968_RS02000
• Protein ID: WP_000384859.1
• Coordinates: 350279..350614 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: S9968_RS01995
• Protein ID: WP_000259017.1
• Coordinates: 350002..350289 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S9968_RS01960	345094..345954	-	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-
S9968_RS01965	346797..347078	-	282	WP_000052406.1	hypothetical protein	-
S9968_RS01970	347112..347498	-	387	WP_000259069.1	hypothetical protein	-
S9968_RS01975	347483..348163	-	681	WP_001865565.1	hypothetical protein	-
S9968_RS01980	348136..348696	-	561	WP_001865562.1	hypothetical protein	-
S9968_RS01985	348696..349103	-	408	WP_000749954.1	hypothetical protein	-
S9968_RS01990	349205..349495	-	291	WP_000078283.1	WXG100 family type VII secretion target	-
S9968_RS01995	350002..350289	+	288	WP_000259017.1	hypothetical protein	Antitoxin
S9968_RS02000	350279..350614	+	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
S9968_RS02005	350919..351389	-	471	WP_000130119.1	hypothetical protein	-
S9968_RS02010	351557..352813	-	1257	WP_000122836.1	plasmid recombination protein	-
S9968_RS02015	353130..353564	-	435	WP_001220482.1	hypothetical protein	-
S9968_RS02020	353600..354475	-	876	WP_000421237.1	hypothetical protein	-
S9968_RS02025	354775..355416	-	642	WP_000591145.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	346398..370019	23621

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T167095 WP_000384859.1 NZ_CP058666:350279-350614 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T167095 NZ_CP074680:265339-265569 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT167095 WP_000259017.1 NZ_CP058666:350002-350289 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT167095 NZ_CP074680:265566-265925 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6