Detailed information of TA system TA167065

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 3036819..3037457
• Replicon: chromosome
• Accession: NZ_CP058661
• Organism: Escherichia coli strain 005008

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: HZR83_RS14550
• Protein ID: WP_001447010.1
• Coordinates: 3036819..3036995 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HZR83_RS14555
• Protein ID: WP_001270286.1
• Coordinates: 3037041..3037457 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR83_RS14530	3032438..3033652	-	1215	WP_001326689.1	BenE family transporter YdcO	-
HZR83_RS14535	3033705..3034241	+	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
HZR83_RS14540	3034314..3036275	+	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
HZR83_RS14545	3036367..3036597	-	231	WP_000494244.1	YncJ family protein	-
HZR83_RS14550	3036819..3036995	+	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
HZR83_RS14555	3037041..3037457	+	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
HZR83_RS14560	3037536..3038942	+	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
HZR83_RS14565	3039187..3040332	+	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
HZR83_RS14570	3040350..3041363	+	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
HZR83_RS14575	3041364..3042305	+	942	WP_001251304.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T167065 WP_001447010.1 NZ_CP058661:3036819-3036995 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T167065 NZ_CP074663:c4128544-4128257 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT167065 WP_001270286.1 NZ_CP058661:3037041-3037457 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT167065 NZ_CP074663:c4128270-4127968 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8