Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3427081..3427699 Replicon chromosome
Accession NZ_CP058651
Organism Escherichia coli strain WCHEC035123

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZR24_RS16600 Protein ID WP_001291435.1
Coordinates 3427481..3427699 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZR24_RS16595 Protein ID WP_000344800.1
Coordinates 3427081..3427455 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR24_RS16585 3422170..3423363 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZR24_RS16590 3423386..3426535 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HZR24_RS16595 3427081..3427455 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZR24_RS16600 3427481..3427699 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HZR24_RS16605 3427871..3428422 + 552 WP_000102568.1 maltose O-acetyltransferase -
HZR24_RS16610 3428538..3429008 + 471 WP_000136192.1 YlaC family protein -
HZR24_RS16615 3429172..3430722 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZR24_RS16620 3430764..3431117 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HZR24_RS16630 3431496..3431807 + 312 WP_000409911.1 MGMT family protein -
HZR24_RS16635 3431838..3432410 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167009 WP_001291435.1 NZ_CP058651:3427481-3427699 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167009 NZ_CP074584:c3869810-3869496 [Enterobacter asburiae]
ATGCATTTAATCTCTATGAAAGCTATTTTGGATGCGGTAACCCAGTTTCCGCAGCACAAGGATGAACTCCTTTTTTTGGG
TCGCACCATCGAAAAGAGCCATTGCCCAACACCTGCTGCTCTGAAAAAACTGTTTCCGACGCTGGATAACTTTAAGTATC
TGGATAAGCATTATGTTATTGATATTGCAAACAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167009 WP_000344800.1 NZ_CP058651:3427081-3427455 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167009 NZ_CP074584:c3869499-3869080 [Enterobacter asburiae]
ATGATGATCGTCGCTGATGCAATGAAAGCTACGCATGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGA
GAAAGATTATGAGGATGCGCTAGAGCTGGTTGAGTATCTTCTTATGAACGAGCCCGATAGCCCCTTGCTGGATATTGTGT
GCGCCAGGATTAGCCGTTACGAAGCCAATCGGCCAGAGATTGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGT
ATTGCGGTTTTAAGAACCTTGATGGATCAGTACAACCTGACGATATCGGATTTTCAGGATGAAATTGGCAGTAAATCGAT
GGTTTCACGGGTTCTGAATGGTCAGAGACAGCTTACTCTGAACCATATTAAAAAGCTGGCGGCGAGGTTTGGGGTATCAC
CTGCGCTGTTTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References