Detailed information of TA system TA167008

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2330806..2332394
• Replicon: chromosome
• Accession: NZ_CP058651
• Organism: Escherichia coli strain WCHEC035123

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: HZR24_RS11285
• Protein ID: WP_001125463.1
• Coordinates: 2331072..2332394 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HZR24_RS11280
• Protein ID: WP_001296726.1
• Coordinates: 2330806..2331072 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR24_RS11280	2330806..2331072	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HZR24_RS11285	2331072..2332394	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
HZR24_RS11290	2332706..2332914	+	209	Protein_2204	helix-turn-helix transcriptional regulator	-
HZR24_RS11295	2333346..2333909	+	564	WP_001373493.1	type 1 fimbrial major subunit FimA	-
HZR24_RS11300	2334270..2334980	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2330806..2348230	17424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T167008 WP_001125463.1 NZ_CP058651:2331072-2332394 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T167008 NZ_CP074584:c3841125-3840727 [Enterobacter asburiae]
ATGAGGCATATGCTGGATACGAATATCGTGAGCCACTTGTTTAAACGACACCCGGAAGTTATAAGCAGAATGACATGTTT
GACTCCGGGGGACGTTTGTATCTCAAGCATTACCGAAGCAGAGTTGCTGTATGGTGCTGATAAGAAGAAAAGCAGTAGAT
TGAAAGAAACAATCCAGGAGTTTCTCAATACCATAACGATTTGCGACTGGGATAGTGAAGCCGCCGCAACGTATGGTGAA
CTCCGCGCAGCAATGGAGAAGAGAGGAAAAGTGATGGGCGATCTCGATCAACTGATCGCTGCGCATGCCATCAGTCGGAG
AACAACGATTGTGACTAACGATCGTGCATTCAGAATGGTGCAGGAGCTTACCGTCGAGGACTGGACGACAACGTCGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT167008 WP_001296726.1 NZ_CP058651:2330806-2331072 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT167008 NZ_CP074584:c3841388-3841122 [Enterobacter asburiae]
ATGGAACGCACAGCAAAACTCTTCAAAAAGGGGCGGCATCAGGCCGTAATGCTACCTGCTGAATTCGCTTTTGATACGGA
GAGCGTCTACATCCGGCGGGATGAGGAGGGGAATGTCGTTTTGGCGGCAAAACCTGTTCAGACAAAGAGTTGGGATACGT
TTTTCCGCATGCTGTCAGTTACGGACGTACCGGATTCGTTTCTGAGCAAAGAGGAACGCAATCAGAGTGTTACGACAAGA
GACCCTCTGGATGGAGCATGTTCATGA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0