166991

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6347334..6347974 Replicon chromosome
Accession NZ_CP058644
Organism Pseudomonas yamanorum strain GZD14026

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HZF02_RS29445 Protein ID WP_155584469.1
Coordinates 6347792..6347974 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZF02_RS29440 Protein ID WP_155584468.1
Coordinates 6347334..6347735 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZF02_RS29415 6342365..6343393 + 1029 WP_179446807.1 IS30 family transposase -
HZF02_RS29420 6343431..6344417 - 987 Protein_5795 AarF/ABC1/UbiB kinase family protein -
HZF02_RS29425 6344529..6345833 - 1305 WP_179448336.1 amidase -
HZF02_RS29430 6345844..6346269 - 426 WP_155584466.1 VOC family protein -
HZF02_RS29435 6346383..6347255 + 873 WP_179448337.1 LysR family transcriptional regulator -
HZF02_RS29440 6347334..6347735 - 402 WP_155584468.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HZF02_RS29445 6347792..6347974 - 183 WP_155584469.1 type II toxin-antitoxin system HicA family toxin Toxin
HZF02_RS29450 6348210..6350570 - 2361 WP_179448338.1 glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase -
HZF02_RS29455 6350767..6351678 + 912 WP_179448339.1 sugar ABC transporter substrate-binding protein -
HZF02_RS29460 6351728..6352210 + 483 WP_155584472.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 6285909..6347974 62065
- flank IS/Tn - - 6342365..6343393 1028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6655.78 Da        Isoelectric Point: 10.9062

>T166991 WP_155584469.1 NZ_CP058644:c6347974-6347792 [Pseudomonas yamanorum]
MRSREVIDLLLVDGWFEVAVKGSHHQFKHSTKPGRVTVPHPKSEIAKGTLHSILKSAGLK

Download         Length: 183 bp

>T166991 NZ_CP074580:1641596-1641814 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14538.26 Da        Isoelectric Point: 4.4943

>AT166991 WP_155584468.1 NZ_CP058644:c6347735-6347334 [Pseudomonas yamanorum]
MKFPVVVHKDADSDYSVTVPDVPGCFSAGTSFSQALDNVREALALHLEGLVADEEALPQAQEVDAHLDNPDFTGGVWAVI
DFDLTPYLGKSVRFNASLPEHLLSRIDERVQKDHRYASRSGFLATAALRELAV

Download         Length: 402 bp

>AT166991 NZ_CP074580:1641195-1641569 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References