Detailed information of TA system TA166985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2450603..2451207
• Replicon: chromosome
• Accession: NZ_CP058644
• Organism: Pseudomonas yamanorum strain GZD14026

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HZF02_RS11250
• Protein ID: WP_169355221.1
• Coordinates: 2450956..2451207 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HZF02_RS11245
• Protein ID: WP_178123571.1
• Coordinates: 2450603..2450959 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZF02_RS11220	2445801..2447330	+	1530	WP_179449778.1	DHA2 family efflux MFS transporter permease subunit	-
HZF02_RS11225	2447342..2447827	-	486	WP_179449779.1	hypothetical protein	-
HZF02_RS11230	2447889..2448323	-	435	WP_179449780.1	hypothetical protein	-
HZF02_RS11235	2448696..2449292	-	597	WP_179449781.1	TetR/AcrR family transcriptional regulator	-
HZF02_RS11240	2449430..2450602	+	1173	WP_155585791.1	MFS transporter	-
HZF02_RS11245	2450603..2450959	-	357	WP_178123571.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HZF02_RS11250	2450956..2451207	-	252	WP_169355221.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9510.09 Da
• Isoelectric Point: 10.2601

>T166985 WP_169355221.1 NZ_CP058644:c2451207-2450956 [Pseudomonas yamanorum]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDKGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGD
LIQ

Nucleotide

• Length: 252 bp

>T166985 NZ_CP074578:c969085-968681 [Pseudomonas syringae]
ATGCTCAAGTACATGCTTGACACCAATATTTGCATTTTCACTATAAAGAACAAGCCAACTTCGGTGCGTGAAGCCTTCAA
CCTCCATCATGGACAGCTATGTATCAGCGCGATCACGTTGATGGAGCTTGTCTACGGCGCAGAAAAGTCTTTGAGCCCCG
AAAGAAACCTTGCCGTTGTAGAGGGTTTCACAGCGCGTCTTGAAGTGCTCCCTTACGACAGCGACGCTGCGGCTCATACC
GGCATGATCAGAGCCGAACTGGCTAGATCGGGCACACCGATCGGCCCGTACGATCAAATGATTGCAGGACACGCCCGCTC
TCTAGGCCTGGTGGTGATCACTAATAATCAGCGTGAATTCCGACGCGTCGAGGGGCTGAGGGTAGAAGACTGGGTAAGCC
AATGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12877.57 Da
• Isoelectric Point: 6.4803

>AT166985 WP_178123571.1 NZ_CP058644:c2450959-2450603 [Pseudomonas yamanorum]
VNNQLKHNGYIGSIEASIEDNCLFGKLLFIKALVSYEGKTVAELEAAFRDAVDDYLDTCHSLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRQKVTLNDLTRQALNEFLQHHGALVTG

Nucleotide

• Length: 357 bp

>AT166985 NZ_CP074578:c969315-969085 [Pseudomonas syringae]
ATGGAACAATCCACAGTCTTCAAAAGCAATCGAAGCCAGGCTGTCCGACTGCCAAAAGCGGTCGCCTTGCCAGACGACGT
GAAACGTGTCGATGTCGTAGCCGTGGGCAGAACCCGCATTATTTCCCCCGCCGGTGAAATGTGGAACAGCTGGTTCGATG
GTGAAAGTGTCAGTGATGATTTCATGGCAGAGCGTGAACAACCAGCCGAACAGCAGCGCGAATCGCTCTGA