Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3634522..3635150 Replicon chromosome
Accession NZ_CP058638
Organism Rhodococcus sp. ZPP

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HYG77_RS17250 Protein ID WP_208960013.1
Coordinates 3634740..3635150 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HYG77_RS17245 Protein ID WP_208960012.1
Coordinates 3634522..3634743 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYG77_RS17220 (HYG77_17190) 3629651..3630451 + 801 WP_208960010.1 SDR family oxidoreductase -
HYG77_RS17225 (HYG77_17195) 3631051..3631452 - 402 WP_109334518.1 hypothetical protein -
HYG77_RS17230 (HYG77_17200) 3631623..3632819 + 1197 WP_244372918.1 histidine kinase -
HYG77_RS17235 (HYG77_17205) 3632816..3633490 + 675 WP_230990003.1 response regulator transcription factor -
HYG77_RS17240 (HYG77_17210) 3633682..3633876 + 195 WP_208960011.1 hypothetical protein -
HYG77_RS40685 3634089..3634217 + 129 WP_280123267.1 hypothetical protein -
HYG77_RS17245 (HYG77_17215) 3634522..3634743 + 222 WP_208960012.1 ribbon-helix-helix domain-containing protein Antitoxin
HYG77_RS17250 (HYG77_17220) 3634740..3635150 + 411 WP_208960013.1 PIN domain nuclease Toxin
HYG77_RS17255 (HYG77_17225) 3635383..3635859 + 477 WP_208960014.1 Lrp/AsnC family transcriptional regulator -
HYG77_RS17260 (HYG77_17230) 3636006..3637205 + 1200 WP_244372920.1 GAF domain-containing protein -
HYG77_RS17265 (HYG77_17235) 3637184..3637444 - 261 WP_208960015.1 DUF3263 domain-containing protein -
HYG77_RS17270 (HYG77_17240) 3637441..3638460 - 1020 WP_208960016.1 lipoyl synthase -
HYG77_RS17275 (HYG77_17245) 3638524..3639933 - 1410 WP_109334508.1 dihydrolipoyl dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-40)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14959.18 Da        Isoelectric Point: 7.3247

>T166981 WP_208960013.1 NZ_CP058638:3634740-3635150 [Rhodococcus sp. ZPP]
MSGSTWLIDKSAMVRLGTSPDAEQWAKRIQRGLVHICTVTLLEVGCSARTAHDLSRGRRTPPLSAMPLEYSTPAVEDRAL
DVQRQLAERGQHRAPSIPDLLIAATAEINNRVVLHLDKDFDLIAAITSQPLERLVA

Download         Length: 411 bp

>T166981 NZ_CP074577:61034-61450 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8405.45 Da        Isoelectric Point: 4.7045

>AT166981 WP_208960012.1 NZ_CP058638:3634522-3634743 [Rhodococcus sp. ZPP]
MPDILIRNFPAEDLALLDEHAARLGISRTEFLRRQLQQEARRTATSVSTADLMRFSQDFPDLNDNEVMRGAWS

Download         Length: 222 bp

>AT166981 NZ_CP074577:60807-61037 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References