Detailed information of TA system TA166979

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4595698..4596365
• Replicon: chromosome
• Accession: NZ_CP058637
• Organism: Enterobacter roggenkampii strain KQ-01

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HZL08_RS21650
• Protein ID: WP_179367079.1
• Coordinates: 4595698..4596027 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HZL08_RS21655
• Protein ID: WP_047358935.1
• Coordinates: 4596048..4596365 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZL08_RS21620	4591300..4591503	+	204	WP_127341473.1	hypothetical protein	-
HZL08_RS21625	4591512..4591697	+	186	WP_127341472.1	hypothetical protein	-
HZL08_RS21630	4591993..4592658	-	666	WP_021241989.1	hypothetical protein	-
HZL08_RS21635	4592655..4593236	-	582	WP_021241990.1	recombinase family protein	-
HZL08_RS21640	4593391..4594502	+	1112	WP_095442581.1	IS3 family transposase	-
HZL08_RS21645	4594650..4595411	-	762	WP_021241992.1	hypothetical protein	-
HZL08_RS21650	4595698..4596027	-	330	WP_179367079.1	TA system toxin CbtA family protein	Toxin
HZL08_RS21655	4596048..4596365	-	318	WP_047358935.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HZL08_RS21660	4596384..4596605	-	222	WP_047062281.1	DUF987 domain-containing protein	-
HZL08_RS21665	4596614..4597096	-	483	WP_032238502.1	DNA repair protein RadC	-
HZL08_RS21670	4597105..4597557	-	453	WP_047358933.1	antirestriction protein	-
HZL08_RS21675	4597643..4597879	-	237	WP_047358932.1	DUF905 domain-containing protein	-
HZL08_RS21680	4597957..4598367	-	411	WP_047358931.1	hypothetical protein	-
HZL08_RS21685	4598432..4598869	-	438	WP_038434461.1	hypothetical protein	-
HZL08_RS21690	4598911..4599447	-	537	WP_047358930.1	DUF4339 domain-containing protein	-
HZL08_RS21695	4599473..4600183	-	711	WP_047358929.1	DeoR family transcriptional regulator	-
HZL08_RS21700	4600392..4601216	-	825	WP_047358928.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4587212..4624589	37377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12370.51 Da
• Isoelectric Point: 9.5732

>T166979 WP_179367079.1 NZ_CP058637:c4596027-4595698 [Enterobacter roggenkampii]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSIGLLKTNVK

Nucleotide

• Length: 330 bp

>T166979 NZ_CP074577:c54872-54567 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11837.43 Da
• Isoelectric Point: 6.8407

>AT166979 WP_047358935.1 NZ_CP058637:c4596365-4596048 [Enterobacter roggenkampii]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECFKLDVAFPHFISQMESMLTTGEMNPRHARCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT166979 NZ_CP074577:c55092-54874 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA