Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4355330..4355987 Replicon chromosome
Accession NZ_CP058637
Organism Enterobacter roggenkampii strain KQ-01

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag HZL08_RS20505 Protein ID WP_021242050.1
Coordinates 4355577..4355987 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag HZL08_RS20500 Protein ID WP_006178375.1
Coordinates 4355330..4355596 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZL08_RS20480 4350764..4352197 - 1434 WP_021242054.1 6-phospho-beta-glucosidase -
HZL08_RS20485 4352314..4353045 - 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
HZL08_RS20490 4353311..4353970 + 660 WP_021242052.1 hemolysin III family protein -
HZL08_RS20495 4354055..4355035 - 981 WP_021242051.1 tRNA-modifying protein YgfZ -
HZL08_RS20500 4355330..4355596 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
HZL08_RS20505 4355577..4355987 + 411 WP_021242050.1 protein YgfX Toxin
HZL08_RS20510 4355994..4356515 - 522 WP_008499710.1 flavodoxin FldB -
HZL08_RS20515 4356617..4357513 + 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
HZL08_RS20520 4357542..4358255 + 714 WP_021242049.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZL08_RS20525 4358261..4359994 + 1734 WP_021242048.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T166978 WP_021242050.1 NZ_CP058637:4355577-4355987 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T166978 NZ_CP074576:4737381-4737758 [Escherichia coli]
ATGACCATTCAGTTTATCTCAGCGGAGGAGATAATTTATTTCCACGATAAATTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTATGAGTATGAAGGCGTTTCTGATCTTT
GGTTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATCTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCATCATACTTGCTGCAAACCCAGAGTTTGTAGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACGCGGTACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT166978 WP_006178375.1 NZ_CP058637:4355330-4355596 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166978 NZ_CP074576:4737163-4737384 [Escherichia coli]
ATGCATACCATGAACTACAGCGAAGCGCGGCAGAACCTTGCATTAGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCAGCTGTGATTATCAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CAGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTAAGGAGTTAGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References