Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2434096..2434716 Replicon chromosome
Accession NZ_CP058637
Organism Enterobacter roggenkampii strain KQ-01

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag HZL08_RS11475 Protein ID WP_008499287.1
Coordinates 2434498..2434716 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag HZL08_RS11470 Protein ID WP_008499288.1
Coordinates 2434096..2434470 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZL08_RS11460 2429224..2430417 + 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZL08_RS11465 2430440..2433586 + 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
HZL08_RS11470 2434096..2434470 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
HZL08_RS11475 2434498..2434716 + 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
HZL08_RS11480 2434923..2435474 + 552 WP_021241634.1 maltose O-acetyltransferase -
HZL08_RS11485 2435592..2436059 + 468 WP_021241635.1 membrane protein -
HZL08_RS11490 2436031..2437491 - 1461 WP_179366824.1 PLP-dependent aminotransferase family protein -
HZL08_RS11495 2437593..2438303 + 711 WP_021241637.1 GNAT family N-acetyltransferase -
HZL08_RS11500 2438300..2438440 - 141 WP_179366825.1 type B 50S ribosomal protein L36 -
HZL08_RS11505 2438443..2438703 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T166976 WP_008499287.1 NZ_CP058637:2434498-2434716 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T166976 NZ_CP074576:4630030-4630137 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT166976 WP_008499288.1 NZ_CP058637:2434096-2434470 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT166976 NZ_CP074576:c4629973-4629916 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References