Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 2434096..2434716 | Replicon | chromosome |
Accession | NZ_CP058637 | ||
Organism | Enterobacter roggenkampii strain KQ-01 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | A0A1H8SI38 |
Locus tag | HZL08_RS11475 | Protein ID | WP_008499287.1 |
Coordinates | 2434498..2434716 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V3PBI9 |
Locus tag | HZL08_RS11470 | Protein ID | WP_008499288.1 |
Coordinates | 2434096..2434470 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HZL08_RS11460 | 2429224..2430417 | + | 1194 | WP_021241633.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
HZL08_RS11465 | 2430440..2433586 | + | 3147 | WP_008499289.1 | multidrug efflux RND transporter permease subunit | - |
HZL08_RS11470 | 2434096..2434470 | + | 375 | WP_008499288.1 | Hha toxicity modulator TomB | Antitoxin |
HZL08_RS11475 | 2434498..2434716 | + | 219 | WP_008499287.1 | hemolysin expression modulator Hha | Toxin |
HZL08_RS11480 | 2434923..2435474 | + | 552 | WP_021241634.1 | maltose O-acetyltransferase | - |
HZL08_RS11485 | 2435592..2436059 | + | 468 | WP_021241635.1 | membrane protein | - |
HZL08_RS11490 | 2436031..2437491 | - | 1461 | WP_179366824.1 | PLP-dependent aminotransferase family protein | - |
HZL08_RS11495 | 2437593..2438303 | + | 711 | WP_021241637.1 | GNAT family N-acetyltransferase | - |
HZL08_RS11500 | 2438300..2438440 | - | 141 | WP_179366825.1 | type B 50S ribosomal protein L36 | - |
HZL08_RS11505 | 2438443..2438703 | - | 261 | WP_006176933.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8612.00 Da Isoelectric Point: 8.9008
>T166976 WP_008499287.1 NZ_CP058637:2434498-2434716 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR
Download Length: 219 bp
>T166976 NZ_CP074576:4630030-4630137 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14481.28 Da Isoelectric Point: 4.8886
>AT166976 WP_008499288.1 NZ_CP058637:2434096-2434470 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC
Download Length: 375 bp
>AT166976 NZ_CP074576:c4629973-4629916 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1H8SI38 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V3PBI9 |