Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2388092..2388726 Replicon chromosome
Accession NZ_CP058624
Organism Treponema denticola strain OMZ 854

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HO345_RS11275 Protein ID WP_253682980.1
Coordinates 2388322..2388726 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HO345_RS11270 Protein ID WP_253682979.1
Coordinates 2388092..2388322 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO345_RS11255 (HO345_11245) 2383646..2384980 - 1335 WP_253682976.1 DUF1015 domain-containing protein -
HO345_RS11260 (HO345_11250) 2385108..2386307 + 1200 WP_253682977.1 coenzyme F420-0:L-glutamate ligase -
HO345_RS11265 (HO345_11255) 2386330..2387895 + 1566 WP_253682978.1 LTA synthase family protein -
HO345_RS11270 (HO345_11260) 2388092..2388322 + 231 WP_253682979.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HO345_RS11275 (HO345_11265) 2388322..2388726 + 405 WP_253682980.1 type II toxin-antitoxin system VapC family toxin Toxin
HO345_RS11280 (HO345_11270) 2388777..2389790 - 1014 WP_253682981.1 tRNA-dihydrouridine synthase family protein -
HO345_RS11285 (HO345_11275) 2389794..2390474 - 681 WP_253682982.1 hypothetical protein -
HO345_RS11290 (HO345_11280) 2390495..2391124 - 630 WP_253682983.1 rhomboid family intramembrane serine protease -
HO345_RS11295 (HO345_11285) 2391146..2392261 - 1116 WP_253682984.1 diguanylate cyclase DgcA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15524.92 Da        Isoelectric Point: 7.7064

>T166967 WP_253682980.1 NZ_CP058624:2388322-2388726 [Treponema denticola]
MYLLDTNICIFLIKNKNLYLKKKIFNCKKEELFLSSITIAELEYGVSKSQFREKNRHALLNFCSDFTNIIDFTTEDTETY
GMIRAYLENKGVPIGPFDTQIAAQGLARNLTVVTNNIREFSRIPGLKVEDWTKE

Download         Length: 405 bp

>T166967 NZ_CP074576:2704824-2705210 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8755.95 Da        Isoelectric Point: 4.7660

>AT166967 WP_253682979.1 NZ_CP058624:2388092-2388322 [Treponema denticola]
MICTKVFTSGNSQAVRIPKEFHIDFSELLIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPAMQEREVF

Download         Length: 231 bp

>AT166967 NZ_CP074576:2705200-2705529 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References