166965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1495266..1495821 Replicon chromosome
Accession NZ_CP058624
Organism Treponema denticola strain OMZ 854

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag HO345_RS07070 Protein ID WP_253676776.1
Coordinates 1495519..1495821 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag HO345_RS07065 Protein ID WP_253684593.1
Coordinates 1495266..1495538 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO345_RS07050 (HO345_07050) 1491206..1493329 - 2124 WP_253682227.1 methyl-accepting chemotaxis protein -
HO345_RS07055 (HO345_07055) 1493336..1494646 - 1311 WP_253682228.1 ABC transporter substrate-binding protein -
HO345_RS07060 (HO345_07060) 1494686..1495237 - 552 WP_253682230.1 hypothetical protein -
HO345_RS07065 (HO345_07065) 1495266..1495538 - 273 WP_253684593.1 BrnA antitoxin family protein Antitoxin
HO345_RS07070 (HO345_07070) 1495519..1495821 - 303 WP_253676776.1 BrnT family toxin Toxin
HO345_RS07075 (HO345_07075) 1495908..1496609 + 702 WP_253682233.1 DNA alkylation repair protein -
HO345_RS07080 (HO345_07080) 1496698..1499544 + 2847 WP_253682235.1 phosphoribosylformylglycinamidine synthase subunit PurL -
HO345_RS07085 (HO345_07085) 1499571..1500128 + 558 WP_010696883.1 TIGR01440 family protein -
HO345_RS07090 1500122..1500640 + 519 WP_253682236.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(8-86)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(33-81)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11586.00 Da        Isoelectric Point: 4.8997

>T166965 WP_253676776.1 NZ_CP058624:c1495821-1495519 [Treponema denticola]
MVRDCFEWDTTKNDNNKRKHGVSFEDAILIFDDPYLLEKYDSKHSEYEDRFLAIGSICGLVLIAVAYTDRAGITRIISAR
SATKAEKELYYDKINEYYGS

Download         Length: 303 bp

>T166965 NZ_CP074576:2340091-2340198 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10442.14 Da        Isoelectric Point: 10.0035

>AT166965 WP_253684593.1 NZ_CP058624:c1495538-1495266 [Treponema denticola]
MNITEAKKNLTKEKIEELKALNDRPIDTSDIPELTKADFLEMYRPIKKPLSIRLDSDIIAWLKSYGKGYQSRINTILRQA
MNTDKKANVF

Download         Length: 273 bp

>AT166965 NZ_CP074576:c2340038-2339977 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References