Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 985737..986302 Replicon chromosome
Accession NZ_CP058624
Organism Treponema denticola strain OMZ 854

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HO345_RS04645 Protein ID WP_253684252.1
Coordinates 985964..986302 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HO345_RS04640 Protein ID WP_253684250.1
Coordinates 985737..985970 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO345_RS04605 (HO345_04595) 982285..982473 + 189 WP_253684241.1 hypothetical protein -
HO345_RS04610 (HO345_04600) 982635..982910 + 276 WP_253684242.1 BrnT family toxin -
HO345_RS04615 (HO345_04605) 982888..983145 + 258 WP_253684244.1 BrnA antitoxin family protein -
HO345_RS04620 (HO345_04610) 983213..983767 + 555 WP_253684246.1 GNAT family protein -
HO345_RS04625 (HO345_04615) 983922..984293 + 372 WP_038125581.1 type II toxin-antitoxin system RelE/ParE family toxin -
HO345_RS04630 (HO345_04620) 984301..984576 + 276 WP_002689021.1 hypothetical protein -
HO345_RS04635 (HO345_04625) 984679..985305 + 627 WP_253684248.1 hypothetical protein -
HO345_RS04640 (HO345_04630) 985737..985970 + 234 WP_253684250.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HO345_RS04645 (HO345_04635) 985964..986302 + 339 WP_253684252.1 endoribonuclease MazF Toxin
HO345_RS04650 (HO345_04640) 986492..986866 + 375 WP_253684254.1 hypothetical protein -
HO345_RS04655 (HO345_04645) 987241..987498 + 258 WP_253684256.1 toxin -
HO345_RS04660 (HO345_04650) 987491..987748 + 258 WP_253684258.1 hypothetical protein -
HO345_RS04665 (HO345_04655) 988027..988485 + 459 WP_253684260.1 hypothetical protein -
HO345_RS04670 (HO345_04660) 988817..989335 + 519 WP_253684262.1 DUF1697 domain-containing protein -
HO345_RS04675 (HO345_04665) 989391..989669 + 279 WP_253684264.1 transposase -
HO345_RS04680 989719..990198 + 480 WP_253684266.1 integrase core domain-containing protein -
HO345_RS04685 (HO345_04675) 990234..990431 + 198 WP_253684268.1 hypothetical protein -
HO345_RS04690 (HO345_04680) 990528..990773 + 246 WP_253684270.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HO345_RS04695 (HO345_04685) 990773..991093 + 321 WP_253684272.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 947853..993264 45411
- inside Integron - - 971220..988551 17331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

SpoVT-AbrB domain

(6-45)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12807.59 Da        Isoelectric Point: 6.2143

>T166964 WP_253684252.1 NZ_CP058624:985964-986302 [Treponema denticola]
MVNSNYVPDRGDLVWLDFNPQAGHEQKGRRPAICISQKRYNQKVGLALFCPITSHIKGYPFEIVLDNHSINGCILSDQVN
NLDYKKRSCDFIEKTTEEEINAVVDNIKLLIE

Download         Length: 339 bp

>T166964 NZ_CP074576:c2148578-2148402 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTAAATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8683.91 Da        Isoelectric Point: 5.0210

>AT166964 WP_253684250.1 NZ_CP058624:985737-985970 [Treponema denticola]
MQVVVQKWGNSLGFRIPSLWAKDNNVKHGSKIEVIAEKGKIVILPQEKTLDDMLAMVTSENIHSEISTDYSVGNEEW

Download         Length: 234 bp

>AT166964 NZ_CP074576:c2148358-2147942 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACTCCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTGAC
GCAGGGAGAAACTGTTGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCTTATTTAACTTGCACCATGCTACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References