Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 898931..899601 Replicon chromosome
Accession NZ_CP058624
Organism Treponema denticola strain OMZ 854

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HO345_RS04130 Protein ID WP_253684080.1
Coordinates 899242..899601 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HO345_RS04125 Protein ID WP_253684078.1
Coordinates 898931..899245 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO345_RS04100 (HO345_04095) 894307..894684 + 378 WP_010697586.1 polymer-forming cytoskeletal protein -
HO345_RS04105 (HO345_04100) 894674..895315 + 642 WP_253684070.1 tetratricopeptide repeat protein -
HO345_RS04110 (HO345_04105) 895319..896725 + 1407 WP_253684072.1 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB -
HO345_RS04115 (HO345_04110) 896790..897932 + 1143 WP_253684074.1 hypothetical protein -
HO345_RS04120 (HO345_04115) 897962..898885 + 924 WP_253684076.1 DMT family transporter -
HO345_RS04125 (HO345_04120) 898931..899245 - 315 WP_253684078.1 putative addiction module antidote protein Antitoxin
HO345_RS04130 (HO345_04125) 899242..899601 - 360 WP_253684080.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HO345_RS04135 (HO345_04130) 899601..900887 - 1287 WP_253684081.1 family 1 glycosylhydrolase -
HO345_RS04140 (HO345_04135) 900998..901543 - 546 WP_253684083.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
HO345_RS04145 (HO345_04140) 901565..902008 - 444 WP_010697578.1 hypothetical protein -
HO345_RS04150 (HO345_04145) 902152..903900 + 1749 WP_002669676.1 energy-dependent translational throttle protein EttA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(20-111)

Antitoxin

Uncharacterized protein HI1420

(2-93)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14062.44 Da        Isoelectric Point: 10.1762

>T166963 WP_253684080.1 NZ_CP058624:c899601-899242 [Treponema denticola]
MNYNRLDSLLFLNYNIDMRTIKKTEVFDTWLSKLKDEKGKAKIIDRIMRLKRGNKGDHRIIDKDIYELRIHFGPGYRIYC
TDKNNEIILLLIAGDKSTQSKDIKKAQQMIKLLEQGDTK

Download         Length: 360 bp

>T166963 NZ_CP074576:2062930-2064246 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGATCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAACAGCTCACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGTGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGCAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACCGTCGGTTAAGCCGAGAATGGTATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11776.33 Da        Isoelectric Point: 5.1199

>AT166963 WP_253684078.1 NZ_CP058624:c899245-898931 [Treponema denticola]
MKITDFDPADYLNTKEAMIEYLNEALKTSIEDNTPEHFTEALGDVTRAQGFTNVAKHTDLNREHLYRSLSKKGNPTFSTI
LKLLNFLGLEINIIDPQTAKPAYC

Download         Length: 315 bp

>AT166963 NZ_CP074576:2062664-2062930 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACCTTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References