166937

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2081999..2082476 Replicon chromosome
Accession NZ_CP058615
Organism Staphylococcus aureus strain 110900

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag HZR12_RS10545 Protein ID WP_000052078.1
Coordinates 2082288..2082476 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HZR12_RS10540 Protein ID WP_001059690.1
Coordinates 2081999..2082259 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR12_RS10505 2077392..2078108 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
HZR12_RS10510 2078256..2078678 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
HZR12_RS10515 2079077..2079571 + 495 WP_048665416.1 GNAT family N-acetyltransferase -
HZR12_RS10520 2079726..2080343 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
HZR12_RS10525 2080416..2080997 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
HZR12_RS10530 2081222..2081458 + 237 WP_000368687.1 hypothetical protein -
HZR12_RS10535 2081455..2081658 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HZR12_RS10540 2081999..2082259 + 261 WP_001059690.1 hypothetical protein Antitoxin
HZR12_RS10545 2082288..2082476 + 189 WP_000052078.1 hypothetical protein Toxin
HZR12_RS10550 2082664..2083233 + 570 WP_001106654.1 hypothetical protein -
HZR12_RS10555 2083321..2083605 + 285 WP_001004395.1 hypothetical protein -
HZR12_RS10560 2083667..2083885 + 219 WP_000005886.1 hypothetical protein -
HZR12_RS10565 2084381..2084581 - 201 WP_001059082.1 cold-shock protein -
HZR12_RS10570 2084938..2085624 - 687 WP_001548082.1 thermonuclease family protein -
HZR12_RS10575 2085966..2086436 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T166937 WP_000052078.1 NZ_CP058615:2082288-2082476 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T166937 NZ_CP074558:c5393078-5392695 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT166937 WP_001059690.1 NZ_CP058615:2081999-2082259 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT166937 NZ_CP074558:c5393320-5393078 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References