Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 862841..863370 Replicon chromosome
Accession NZ_CP058615
Organism Staphylococcus aureus strain 110900

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag HZR12_RS04315 Protein ID WP_001103933.1
Coordinates 863053..863370 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag HZR12_RS04310 Protein ID WP_001058487.1
Coordinates 862841..863050 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR12_RS04275 858072..858356 + 285 WP_000917289.1 co-chaperone GroES -
HZR12_RS04280 858432..860048 + 1617 WP_000240645.1 chaperonin GroEL -
HZR12_RS04285 860117..861289 - 1173 WP_000179353.1 site-specific integrase -
HZR12_RS04290 861303..862025 - 723 WP_000672427.1 helix-turn-helix domain-containing protein -
HZR12_RS04295 862178..862384 + 207 WP_000794657.1 helix-turn-helix transcriptional regulator -
HZR12_RS04300 862388..862705 + 318 WP_000481968.1 helix-turn-helix domain-containing protein -
HZR12_RS04305 862702..862848 + 147 WP_000708434.1 hypothetical protein -
HZR12_RS04310 862841..863050 + 210 WP_001058487.1 hypothetical protein Antitoxin
HZR12_RS04315 863053..863370 + 318 WP_001103933.1 DUF1474 family protein Toxin
HZR12_RS04320 863437..864306 + 870 WP_001002699.1 primase alpha helix C-terminal domain-containing protein -
HZR12_RS04325 864323..865792 + 1470 WP_001838755.1 virulence-associated E family protein -
HZR12_RS04330 866078..866440 + 363 WP_001039169.1 hypothetical protein -
HZR12_RS04335 866442..866726 + 285 WP_000998179.1 hypothetical protein -
HZR12_RS04340 866723..867364 + 642 WP_001019811.1 hypothetical protein -
HZR12_RS04345 867899..868240 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hld / groEL 848489..885270 36781


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T166933 WP_001103933.1 NZ_CP058615:863053-863370 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T166933 NZ_CP074558:4193055-4193273 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT166933 WP_001058487.1 NZ_CP058615:862841-863050 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT166933 NZ_CP074558:4192654-4193028 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References