Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 809642..810171 Replicon chromosome
Accession NZ_CP058615
Organism Staphylococcus aureus strain 110900

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HZR12_RS04035 Protein ID WP_000621175.1
Coordinates 809809..810171 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag HZR12_RS04030 Protein ID WP_000948331.1
Coordinates 809642..809812 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR12_RS04000 804678..805238 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
HZR12_RS04005 805447..805926 + 480 WP_001287088.1 hypothetical protein -
HZR12_RS04010 805919..807502 + 1584 WP_001294626.1 PH domain-containing protein -
HZR12_RS04015 807489..807980 + 492 WP_001205910.1 PH domain-containing protein -
HZR12_RS04020 807984..808343 + 360 WP_000581200.1 holo-ACP synthase -
HZR12_RS04025 808409..809557 + 1149 WP_001281145.1 alanine racemase -
HZR12_RS04030 809642..809812 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HZR12_RS04035 809809..810171 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HZR12_RS04040 810521..811522 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
HZR12_RS04045 811641..811967 + 327 WP_001052491.1 anti-sigma factor antagonist -
HZR12_RS04050 811969..812448 + 480 WP_001190829.1 anti-sigma B factor RsbW -
HZR12_RS04055 812423..813193 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T166932 WP_000621175.1 NZ_CP058615:809809-810171 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T166932 NZ_CP074558:c2617665-2617563 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT166932 WP_000948331.1 NZ_CP058615:809642-809812 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT166932 NZ_CP074558:2617556-2617701 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References