Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 860186..860663 Replicon chromosome
Accession NZ_CP058613
Organism Staphylococcus aureus strain 128254

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag HZR13_RS04295 Protein ID WP_000052078.1
Coordinates 860186..860374 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HZR13_RS04300 Protein ID WP_001059690.1
Coordinates 860403..860663 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR13_RS04265 856226..856696 + 471 WP_000824472.1 hypothetical protein -
HZR13_RS04270 857038..857724 + 687 WP_001548082.1 thermonuclease family protein -
HZR13_RS04275 858081..858281 + 201 WP_001059082.1 cold-shock protein -
HZR13_RS04280 858777..858995 - 219 WP_000005886.1 hypothetical protein -
HZR13_RS04285 859057..859341 - 285 WP_001004395.1 hypothetical protein -
HZR13_RS04290 859429..859998 - 570 WP_001106654.1 hypothetical protein -
HZR13_RS04295 860186..860374 - 189 WP_000052078.1 hypothetical protein Toxin
HZR13_RS04300 860403..860663 - 261 WP_001059690.1 hypothetical protein Antitoxin
HZR13_RS04305 861004..861207 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HZR13_RS04310 861204..861440 - 237 WP_000368687.1 hypothetical protein -
HZR13_RS04315 861665..862246 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
HZR13_RS04320 862295..862912 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
HZR13_RS04325 863067..863561 - 495 WP_048665416.1 GNAT family N-acetyltransferase -
HZR13_RS04330 863960..864382 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
HZR13_RS04335 864530..865246 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hld / groEL / vWbp 814430..935693 121263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T166918 WP_000052078.1 NZ_CP058613:c860374-860186 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T166918 NZ_CP074553:2112561-2112663 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT166918 WP_001059690.1 NZ_CP058613:c860663-860403 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT166918 NZ_CP074553:c2112670-2112525 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References