Detailed information of TA system TA166917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 833157..833686
• Replicon: chromosome
• Accession: NZ_CP058613
• Organism: Staphylococcus aureus strain 128254

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: HZR13_RS04140
• Protein ID: WP_181666393.1
• Coordinates: 833369..833686 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A6B0BJC0
• Locus tag: HZR13_RS04135
• Protein ID: WP_001058487.1
• Coordinates: 833157..833366 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR13_RS04100	828388..828672	+	285	WP_000917289.1	co-chaperone GroES	-
HZR13_RS04105	828748..830364	+	1617	WP_000240645.1	chaperonin GroEL	-
HZR13_RS04110	830433..831605	-	1173	WP_000179353.1	site-specific integrase	-
HZR13_RS04115	831619..832341	-	723	WP_000672427.1	helix-turn-helix domain-containing protein	-
HZR13_RS04120	832494..832700	+	207	WP_000794657.1	helix-turn-helix transcriptional regulator	-
HZR13_RS04125	832704..833021	+	318	WP_000481968.1	helix-turn-helix domain-containing protein	-
HZR13_RS04130	833018..833164	+	147	WP_000708434.1	hypothetical protein	-
HZR13_RS04135	833157..833366	+	210	WP_001058487.1	hypothetical protein	Antitoxin
HZR13_RS04140	833369..833686	+	318	WP_181666393.1	DUF1474 family protein	Toxin
HZR13_RS04145	833753..834622	+	870	WP_001002699.1	primase alpha helix C-terminal domain-containing protein	-
HZR13_RS04150	834639..836108	+	1470	WP_001838755.1	virulence-associated E family protein	-
HZR13_RS04155	836394..836756	+	363	WP_001039169.1	hypothetical protein	-
HZR13_RS04160	836758..837042	+	285	WP_000998179.1	hypothetical protein	-
HZR13_RS04165	837039..837680	+	642	WP_001019811.1	hypothetical protein	-
HZR13_RS04170	838215..838556	+	342	WP_001190614.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hld / groEL / vWbp	814430..935693	121263

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12541.16 Da
• Isoelectric Point: 4.6364

>T166917 WP_181666393.1 NZ_CP058613:833369-833686 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKTSSENFGEESDDAKKLKITE

Nucleotide

• Length: 318 bp

>T166917 NZ_CP074553:869842-870252 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8228.24 Da
• Isoelectric Point: 4.1682

>AT166917 WP_001058487.1 NZ_CP058613:833157-833366 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT166917 NZ_CP074553:869595-869861 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A6B0BJC0