Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4796034..4797022 Replicon chromosome
Accession NZ_CP058596
Organism Escherichia coli strain UPEC_U013

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag HYE75_RS23155 Protein ID WP_014640052.1
Coordinates 4796034..4796420 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag HYE75_RS23160 Protein ID WP_021538830.1
Coordinates 4796450..4797022 (-) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYE75_RS23100 4791419..4791907 + 489 WP_187973580.1 5'-deoxynucleotidase -
HYE75_RS23105 4791898..4792260 + 363 WP_001242718.1 phage protein -
HYE75_RS23110 4792257..4792460 + 204 WP_000111289.1 hypothetical protein -
HYE75_RS23115 4792453..4792701 + 249 WP_000476209.1 hypothetical protein -
HYE75_RS23120 4792688..4793359 + 672 WP_187973549.1 ead/Ea22-like family protein -
HYE75_RS23125 4793359..4793850 + 492 WP_089046484.1 hypothetical protein -
HYE75_RS23130 4793852..4794139 + 288 WP_000212745.1 hypothetical protein -
HYE75_RS23135 4794143..4794883 + 741 WP_023145274.1 hypothetical protein -
HYE75_RS23140 4794883..4795455 + 573 WP_023145273.1 3'-5' exoribonuclease -
HYE75_RS23145 4795492..4795773 + 282 WP_001093916.1 pyocin activator PrtN family protein -
HYE75_RS23150 4795821..4795994 - 174 WP_021538831.1 hypothetical protein -
HYE75_RS23155 4796034..4796420 - 387 WP_014640052.1 hypothetical protein Toxin
HYE75_RS23160 4796450..4797022 - 573 WP_021538830.1 SocA family protein Antitoxin
HYE75_RS23165 4797496..4798011 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
HYE75_RS23170 4798053..4798262 - 210 WP_001296638.1 CsbD family protein -
HYE75_RS23175 4798378..4799703 - 1326 WP_001296637.1 MATE family efflux transporter DinF -
HYE75_RS23180 4799776..4800384 - 609 WP_000646078.1 transcriptional repressor LexA -
HYE75_RS23185 4800494..4800862 - 369 WP_000002907.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4757585..4808851 51266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-137)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T166905 WP_014640052.1 NZ_CP058596:c4796420-4796034 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T166905 NZ_CP074543:43428-43844 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21987.31 Da        Isoelectric Point: 5.6404

>AT166905 WP_021538830.1 NZ_CP058596:c4797022-4796450 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHDPGYSRKPIDLKEMLI
SEGKSEDEANHIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT166905 NZ_CP074543:43201-43431 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References