Detailed information of TA system TA166903

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4466213..4466892
• Replicon: chromosome
• Accession: NZ_CP058596
• Organism: Escherichia coli strain UPEC_U013

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HYE75_RS21490
• Protein ID: WP_129321009.1
• Coordinates: 4466213..4466554 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HYE75_RS21495
• Protein ID: WP_187809078.1
• Coordinates: 4466575..4466892 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYE75_RS21475	4462801..4463874	-	1074	WP_001327207.1	integrase arm-type DNA-binding domain-containing protein	-
HYE75_RS21480	4464236..4465033	-	798	WP_080395547.1	helix-turn-helix transcriptional regulator	-
HYE75_RS21485	4465265..4466098	-	834	WP_187809079.1	DUF4942 domain-containing protein	-
HYE75_RS21490	4466213..4466554	-	342	WP_129321009.1	TA system toxin CbtA family protein	Toxin
HYE75_RS21495	4466575..4466892	-	318	WP_187809078.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HYE75_RS21500	4466912..4467133	-	222	WP_048981705.1	DUF987 domain-containing protein	-
HYE75_RS21505	4467142..4467618	-	477	WP_187973533.1	RadC family protein	-
HYE75_RS21510	4467634..4468092	-	459	WP_187973534.1	antirestriction protein	-
HYE75_RS21515	4468194..4468433	-	240	WP_187973535.1	DUF905 domain-containing protein	-
HYE75_RS21520	4468510..4468977	-	468	WP_187973536.1	hypothetical protein	-
HYE75_RS21525	4469001..4469444	-	444	WP_187973537.1	hypothetical protein	-
HYE75_RS21530	4469444..4469680	-	237	WP_001115854.1	hypothetical protein	-
HYE75_RS21535	4469717..4470418	-	702	WP_187973538.1	WYL domain-containing protein	-
HYE75_RS21540	4470635..4471456	-	822	WP_187973539.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4443211..4483870	40659

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12864.85 Da
• Isoelectric Point: 7.8561

>T166903 WP_129321009.1 NZ_CP058596:c4466554-4466213 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLQAVDILRARQATGLLQQSRSNVVR

Nucleotide

• Length: 342 bp

>T166903 NZ_CP074541:c5430018-5429635 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11984.56 Da
• Isoelectric Point: 7.0267

>AT166903 WP_187809078.1 NZ_CP058596:c4466892-4466575 [Escherichia coli]
MTHITWGLQRAITPRLGARLVQEGNRLHYLGDRASITGKFSDTECRKLDETFPHFIRQMESMLTTGEMNPRHAHCVTLYH
NDFTCEADTLGSCGYVYIAIYSTQS

Nucleotide

• Length: 318 bp

>AT166903 NZ_CP074541:c5430260-5430018 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA