Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4096759..4097557 Replicon chromosome
Accession NZ_CP058596
Organism Escherichia coli strain UPEC_U013

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag HYE75_RS19760 Protein ID WP_000854730.1
Coordinates 4097180..4097557 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag HYE75_RS19755 Protein ID WP_001285482.1
Coordinates 4096759..4097133 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYE75_RS19715 4092734..4093186 + 453 WP_000682723.1 hypothetical protein -
HYE75_RS19720 4093304..4093537 + 234 WP_001213776.1 DUF905 family protein -
HYE75_RS19725 4093637..4094458 + 822 WP_001234359.1 DUF945 domain-containing protein -
HYE75_RS19730 4094458..4094703 + 246 WP_001164966.1 hypothetical protein -
HYE75_RS19735 4094797..4095270 + 474 WP_001537423.1 antirestriction protein -
HYE75_RS19740 4095286..4095762 + 477 WP_001186170.1 RadC family protein -
HYE75_RS19745 4095825..4096046 + 222 WP_000692315.1 DUF987 domain-containing protein -
HYE75_RS19750 4096065..4096709 + 645 WP_000086763.1 hypothetical protein -
HYE75_RS19755 4096759..4097133 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HYE75_RS19760 4097180..4097557 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
HYE75_RS19765 4097554..4098046 + 493 Protein_3879 hypothetical protein -
HYE75_RS19770 4098125..4099113 - 989 Protein_3880 IS630 family transposase -
HYE75_RS19775 4099261..4099449 - 189 Protein_3881 IS66 family transposase -
HYE75_RS19780 4099510..4100643 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
HYE75_RS19785 4100897..4102301 - 1405 Protein_3883 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T166895 WP_000854730.1 NZ_CP058596:4097180-4097557 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T166895 NZ_CP074541:737555-738040 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT166895 WP_001285482.1 NZ_CP058596:4096759-4097133 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT166895 NZ_CP074541:737265-737558 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References