Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1970928..1971759 Replicon chromosome
Accession NZ_CP058596
Organism Escherichia coli strain UPEC_U013

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HYE75_RS09240 Protein ID WP_000854814.1
Coordinates 1970928..1971302 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag HYE75_RS09245 Protein ID WP_001285586.1
Coordinates 1971391..1971759 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYE75_RS09200 1966324..1967490 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
HYE75_RS09205 1967609..1968082 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
HYE75_RS09210 1968280..1969338 + 1059 WP_001200890.1 FUSC family protein -
HYE75_RS09215 1969510..1969839 + 330 WP_000450409.1 DUF496 family protein -
HYE75_RS09220 1969940..1970122 - 183 WP_001016348.1 hypothetical protein -
HYE75_RS09225 1970176..1970322 + 147 Protein_1807 transposase domain-containing protein -
HYE75_RS09230 1970611..1970724 - 114 WP_001161660.1 DUF957 domain-containing protein -
HYE75_RS09235 1970737..1970931 - 195 WP_000988601.1 hypothetical protein -
HYE75_RS09240 1970928..1971302 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HYE75_RS09245 1971391..1971759 - 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HYE75_RS09250 1971833..1972054 - 222 WP_000692323.1 DUF987 domain-containing protein -
HYE75_RS09255 1972123..1972599 - 477 WP_021537752.1 RadC family protein -
HYE75_RS09260 1972615..1973100 - 486 WP_000213703.1 antirestriction protein -
HYE75_RS09265 1973191..1974012 - 822 WP_001234569.1 DUF945 domain-containing protein -
HYE75_RS09270 1974233..1974643 - 411 WP_000846704.1 hypothetical protein -
HYE75_RS09275 1974659..1975336 - 678 WP_001362823.1 hypothetical protein -
HYE75_RS09280 1975472..1976542 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T166882 WP_000854814.1 NZ_CP058596:c1971302-1970928 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T166882 NZ_CP074539:350588-350935 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT166882 WP_001285586.1 NZ_CP058596:c1971759-1971391 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT166882 NZ_CP074539:350935-351234 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References