Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 892552..893384 Replicon chromosome
Accession NZ_CP058596
Organism Escherichia coli strain UPEC_U013

Toxin (Protein)


Gene name yeeV Uniprot ID A0A426P9T8
Locus tag HYE75_RS04315 Protein ID WP_001555674.1
Coordinates 892552..892926 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A085P7I7
Locus tag HYE75_RS04320 Protein ID WP_001327592.1
Coordinates 893016..893384 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYE75_RS04290 888614..889597 - 984 WP_001336760.1 KpsF/GutQ family sugar-phosphate isomerase -
HYE75_RS04295 890408..890578 - 171 Protein_845 IS110 family transposase -
HYE75_RS04300 890920..891762 - 843 WP_001519083.1 DUF4942 domain-containing protein -
HYE75_RS04305 891847..892044 - 198 WP_000445282.1 DUF957 domain-containing protein -
HYE75_RS04310 892064..892555 - 492 WP_001555675.1 hypothetical protein -
HYE75_RS04315 892552..892926 - 375 WP_001555674.1 TA system toxin CbtA family protein Toxin
HYE75_RS04320 893016..893384 - 369 WP_001327592.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HYE75_RS04325 893547..893768 - 222 WP_000692323.1 DUF987 domain-containing protein -
HYE75_RS04330 893837..894313 - 477 WP_001487922.1 RadC family protein -
HYE75_RS04335 894329..894808 - 480 WP_000706981.1 antirestriction protein -
HYE75_RS04340 895147..895965 - 819 WP_001555673.1 DUF945 domain-containing protein -
HYE75_RS04345 896055..896288 - 234 WP_001278282.1 DUF905 family protein -
HYE75_RS04350 896294..896971 - 678 WP_001555672.1 hypothetical protein -
HYE75_RS04355 897119..897799 - 681 WP_001555671.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14205.16 Da        Isoelectric Point: 8.2918

>T166878 WP_001555674.1 NZ_CP058596:c892926-892552 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAK

Download         Length: 375 bp

>T166878 NZ_CP074535:c5516467-5516084 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13901.65 Da        Isoelectric Point: 6.3165

>AT166878 WP_001327592.1 NZ_CP058596:c893384-893016 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT166878 NZ_CP074535:c5516709-5516467 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A426P9T8

Antitoxin

Source ID Structure
AlphaFold DB A0A085P7I7

References