166814

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2462681..2463319 Replicon chromosome
Accession NZ_CP058571
Organism Escherichia coli strain EC2

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HX136_RS12085 Protein ID WP_000813794.1
Coordinates 2462681..2462857 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HX136_RS12090 Protein ID WP_001270286.1
Coordinates 2462903..2463319 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HX136_RS12065 2458300..2459514 - 1215 WP_001326689.1 BenE family transporter YdcO -
HX136_RS12070 2459567..2460103 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HX136_RS12075 2460176..2462137 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HX136_RS12080 2462229..2462459 - 231 WP_000494244.1 YncJ family protein -
HX136_RS12085 2462681..2462857 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HX136_RS12090 2462903..2463319 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HX136_RS12095 2463398..2464804 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HX136_RS12100 2465049..2466194 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HX136_RS12105 2466212..2467225 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
HX136_RS12110 2467226..2468167 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T166814 WP_000813794.1 NZ_CP058571:2462681-2462857 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T166814 NZ_CP074448:3454737-3455039 [Enterobacter asburiae]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTTGGGGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTACAGACTCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT166814 WP_001270286.1 NZ_CP058571:2462903-2463319 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT166814 NZ_CP074448:3455046-3455333 [Enterobacter asburiae]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCGCTGGGCGTCATCGCGCGCGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCTGGAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References