166807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 913273..913927 Replicon chromosome
Accession NZ_CP058571
Organism Escherichia coli strain EC2

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag HX136_RS04375 Protein ID WP_000244777.1
Coordinates 913520..913927 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HX136_RS04370 Protein ID WP_000354046.1
Coordinates 913273..913539 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HX136_RS04345 908442..909185 + 744 WP_000951964.1 SDR family oxidoreductase -
HX136_RS04350 909242..910675 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
HX136_RS04355 910720..911031 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
HX136_RS04360 911195..911854 + 660 WP_000250274.1 hemolysin III family protein -
HX136_RS04365 912050..913030 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HX136_RS04370 913273..913539 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HX136_RS04375 913520..913927 + 408 WP_000244777.1 toxin CptA Toxin
HX136_RS04380 913967..914488 - 522 WP_001055874.1 flavodoxin FldB -
HX136_RS04385 914600..915496 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HX136_RS04390 915521..916231 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HX136_RS04395 916237..917970 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T166807 WP_000244777.1 NZ_CP058571:913520-913927 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T166807 NZ_CP074446:c4625749-4625465 [Klebsiella aerogenes]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATGGAGTCGGCCAGGTTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCGTCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT166807 WP_000354046.1 NZ_CP058571:913273-913539 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166807 NZ_CP074446:c4625981-4625739 [Klebsiella aerogenes]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References