Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1462320..1462960 Replicon chromosome
Accession NZ_CP058559
Organism Alkalicella caledoniensis strain LB2

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag HYG86_RS07125 Protein ID WP_213168371.1
Coordinates 1462320..1462670 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HYG86_RS07130 Protein ID WP_213168373.1
Coordinates 1462676..1462960 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYG86_RS07110 (HYG86_07115) 1458655..1459812 - 1158 WP_213168366.1 DUF362 domain-containing protein -
HYG86_RS07115 (HYG86_07120) 1460016..1460723 - 708 WP_213168368.1 hypothetical protein -
HYG86_RS07120 (HYG86_07125) 1461066..1462067 - 1002 WP_213168369.1 asparaginase -
HYG86_RS07125 (HYG86_07130) 1462320..1462670 - 351 WP_213168371.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HYG86_RS07130 (HYG86_07135) 1462676..1462960 - 285 WP_213168373.1 ribbon-helix-helix protein, CopG family Antitoxin
HYG86_RS07135 (HYG86_07140) 1463053..1464159 - 1107 WP_213168375.1 alanine racemase -
HYG86_RS07140 (HYG86_07145) 1464266..1464772 - 507 WP_213168377.1 hypothetical protein -
HYG86_RS07145 (HYG86_07150) 1464785..1465237 - 453 WP_213168379.1 CBS domain-containing protein -
HYG86_RS07150 (HYG86_07155) 1465242..1466735 - 1494 WP_213168381.1 NAD(P)H-hydrate dehydratase -
HYG86_RS07155 (HYG86_07160) 1466737..1467102 - 366 WP_213168383.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12841.85 Da        Isoelectric Point: 6.4724

>T166802 WP_213168371.1 NZ_CP058559:c1462670-1462320 [Alkalicella caledoniensis]
MSVKRGDVYYADLSPVVGSEQGGIRPVLVIQNDVGNRYSPTVIVAAITSQIQKAKLPTHVEVEAAKYGLEKDSVILLEQI
RTIDKQRLNEKVAHIGEDKMVRINEALQISLALIEF

Download         Length: 351 bp

>T166802 NZ_CP074446:1976754-1976857 [Klebsiella aerogenes]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10834.52 Da        Isoelectric Point: 5.1867

>AT166802 WP_213168373.1 NZ_CP058559:c1462960-1462676 [Alkalicella caledoniensis]
MAETRRVMISVPDNLLQELDIIVKRDKLNRSQLIREAVKLYIGERYNKQRSIVNKELMQRGYVEMSEINLNLANEALNAE
NEAVNVVEQMVCGA

Download         Length: 285 bp

>AT166802 NZ_CP074446:c1976865-1976719 [Klebsiella aerogenes]
TAATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTGACTGTGACAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References