Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 373657..374284 Replicon chromosome
Accession NZ_CP058557
Organism Alkaliphilus sp. B6464

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HYG84_RS01700 Protein ID WP_212380204.1
Coordinates 373657..374007 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HYG84_RS01705 Protein ID WP_212380206.1
Coordinates 374009..374284 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYG84_RS01680 (HYG84_01675) 368807..369532 - 726 WP_212380195.1 WecB/TagA/CpsF family glycosyltransferase -
HYG84_RS01685 (HYG84_01680) 369529..370626 - 1098 WP_212380198.1 polysaccharide pyruvyl transferase CsaB -
HYG84_RS01690 (HYG84_01685) 370626..372791 - 2166 WP_212380200.1 DUF5693 family protein -
HYG84_RS01695 (HYG84_01690) 372897..373394 - 498 WP_212380202.1 hypothetical protein -
HYG84_RS01700 (HYG84_01695) 373657..374007 - 351 WP_212380204.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HYG84_RS01705 (HYG84_01700) 374009..374284 - 276 WP_212380206.1 ribbon-helix-helix protein, CopG family Antitoxin
HYG84_RS01710 (HYG84_01705) 374381..375553 - 1173 WP_212380208.1 alanine racemase -
HYG84_RS01715 (HYG84_01710) 375590..376213 - 624 WP_212380210.1 outer membrane lipoprotein carrier protein LolA -
HYG84_RS01720 (HYG84_01715) 376241..376609 - 369 WP_212380212.1 holo-ACP synthase -
HYG84_RS01725 (HYG84_01720) 376776..377459 - 684 WP_212380214.1 hypothetical protein -
HYG84_RS01730 (HYG84_01725) 377606..378616 + 1011 WP_212380216.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12878.98 Da        Isoelectric Point: 5.7362

>T166801 WP_212380204.1 NZ_CP058557:c374007-373657 [Alkaliphilus sp. B6464]
VIIKRGDIFYADLSPVIGSEQGGVRPVLVVQNDIGNRYSPTVIIVAITSQINKAKLPTHVEIKSSDYGLPKDSVLLLEQI
RTIDKRRLEEKIGHVTEDIMEKVNEALLVSLGLIEF

Download         Length: 351 bp

>T166801 NZ_CP074446:841032-841442 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGTATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGAGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10589.32 Da        Isoelectric Point: 4.4519

>AT166801 WP_212380206.1 NZ_CP058557:c374284-374009 [Alkaliphilus sp. B6464]
MADSKRIMISLPDSLLQEVDNIVSIEKTNRSEFIREAMKLYIRERNKMELREQMKKGYQEMGLINLALAELGLSLDMSLL
ETYEAQMAECE

Download         Length: 276 bp

>AT166801 NZ_CP074446:840785-841051 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References