Detailed information of TA system TA166799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2711341..2711866
• Replicon: chromosome
• Accession: NZ_CP058556
• Organism: Streptomyces sp. CB04723

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HXS80_RS11435
• Protein ID: WP_098008089.1
• Coordinates: 2711603..2711866 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HXS80_RS11430
• Protein ID: WP_098008088.1
• Coordinates: 2711341..2711610 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HXS80_RS11410	2706872..2707324	+	453	WP_030195266.1	carboxymuconolactone decarboxylase family protein	-
HXS80_RS11415	2707420..2708622	+	1203	WP_179181594.1	MFS transporter	-
HXS80_RS11420	2708669..2710300	-	1632	WP_179181595.1	DHA2 family efflux MFS transporter permease subunit	-
HXS80_RS11425	2710423..2710911	+	489	WP_179181596.1	MarR family transcriptional regulator	-
HXS80_RS11430	2711341..2711610	+	270	WP_098008088.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HXS80_RS11435	2711603..2711866	+	264	WP_098008089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HXS80_RS11440	2712463..2713551	-	1089	WP_030115335.1	redox-regulated ATPase YchF	-
HXS80_RS11445	2714195..2714833	+	639	WP_179181597.1	hypothetical protein	-
HXS80_RS11450	2715031..2715780	-	750	WP_179181598.1	ROK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (7-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10011.47 Da
• Isoelectric Point: 9.5290

>T166799 WP_098008089.1 NZ_CP058556:2711603-2711866 [Streptomyces sp. CB04723]
VSEYRTVFRPEAQAELRKIPRDTALRILAKLAELESDPLGFSTTALVSQPERRRLRVGDYRIVYTIDKGELVVWVVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T166799 NZ_CP074444:15564-15980 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10289.85 Da
• Isoelectric Point: 5.2273

>AT166799 WP_098008088.1 NZ_CP058556:2711341-2711610 [Streptomyces sp. CB04723]
MTQPLPIKSIRDVRAHLAEVVERADRDDMPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT166799 NZ_CP074444:15337-15567 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA