Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2628081..2628597 Replicon chromosome
Accession NZ_CP058548
Organism Klebsiella pneumoniae strain S165-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HXT63_RS12985 Protein ID WP_040216106.1
Coordinates 2628313..2628597 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HXT63_RS12980 Protein ID WP_064162488.1
Coordinates 2628081..2628323 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT63_RS12965 (2624109) 2624109..2624849 + 741 WP_002886899.1 KDGP aldolase family protein -
HXT63_RS12970 (2624916) 2624916..2626070 + 1155 WP_064162489.1 lactonase family protein -
HXT63_RS12975 (2626093) 2626093..2628003 + 1911 WP_023325426.1 PRD domain-containing protein -
HXT63_RS12980 (2628081) 2628081..2628323 + 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HXT63_RS12985 (2628313) 2628313..2628597 + 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXT63_RS12990 (2628601) 2628601..2629065 - 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HXT63_RS12995 (2629373) 2629373..2631511 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HXT63_RS13000 (2631868) 2631868..2632611 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HXT63_RS13005 (2632614) 2632614..2632787 - 174 WP_032425422.1 hypothetical protein -
HXT63_RS13010 (2632917) 2632917..2633180 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T166787 WP_040216106.1 NZ_CP058548:2628313-2628597 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T166787 NZ_CP074442:325718-326086 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT166787 WP_064162488.1 NZ_CP058548:2628081-2628323 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT166787 NZ_CP074442:325500-325721 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References