Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1978307..1978987 Replicon chromosome
Accession NZ_CP058548
Organism Klebsiella pneumoniae strain S165-1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HXT63_RS09880 Protein ID WP_039026306.1
Coordinates 1978646..1978987 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HXT63_RS09875 Protein ID WP_039026307.1
Coordinates 1978307..1978624 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT63_RS09835 (1973414) 1973414..1974238 + 825 WP_039026313.1 DUF932 domain-containing protein -
HXT63_RS09840 (1974447) 1974447..1975145 + 699 WP_039026312.1 DeoR family transcriptional regulator -
HXT63_RS09845 (1975473) 1975473..1975688 + 216 WP_039026311.1 hypothetical protein -
HXT63_RS09850 (1975739) 1975739..1976674 + 936 WP_072038556.1 Ivy family c-type lysozyme inhibitor -
HXT63_RS09855 (1976770) 1976770..1976994 + 225 WP_039026310.1 DUF905 domain-containing protein -
HXT63_RS09860 (1977109) 1977109..1977567 + 459 WP_039026309.1 antirestriction protein -
HXT63_RS09865 (1977583) 1977583..1978059 + 477 WP_039026308.1 RadC family protein -
HXT63_RS09870 (1978068) 1978068..1978289 + 222 WP_000691995.1 DUF987 domain-containing protein -
HXT63_RS09875 (1978307) 1978307..1978624 + 318 WP_039026307.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HXT63_RS09880 (1978646) 1978646..1978987 + 342 WP_039026306.1 TA system toxin CbtA family protein Toxin
HXT63_RS09885 (1979103) 1979103..1979936 + 834 WP_237086680.1 DUF4942 domain-containing protein -
HXT63_RS09890 (1980462) 1980462..1980929 + 468 WP_002922963.1 DUF3237 domain-containing protein -
HXT63_RS09895 (1981042) 1981042..1982049 + 1008 WP_002922964.1 zinc-binding alcohol dehydrogenase family protein -
HXT63_RS09900 (1982051) 1982051..1982341 + 291 WP_002922965.1 putative quinol monooxygenase -
HXT63_RS09905 (1982392) 1982392..1983090 - 699 WP_062920389.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1960027..1978987 18960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12825.82 Da        Isoelectric Point: 9.7153

>T166785 WP_039026306.1 NZ_CP058548:1978646-1978987 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSTVAVWQMLLTRLLEQHYGLTLNDTPFSDVTVIQEHINAGITLADAVNFLVEKYELVRIDRRSF
NCQEQSPYIRAVDILRARQATGLLRQSRNNAVR

Download         Length: 342 bp

>T166785 NZ_CP074437:3251728-3251831 [Klebsiella sp. A52]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11891.45 Da        Isoelectric Point: 6.9456

>AT166785 WP_039026307.1 NZ_CP058548:1978307-1978624 [Klebsiella pneumoniae]
MSNTTWGLQRDITPRMGARLVQEGNRLHYLADRASITSKFSDAECQKLDIAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGYTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT166785 NZ_CP074437:c3251836-3251693 [Klebsiella sp. A52]
CAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTGACTGTGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References