Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1365097..1365776 Replicon chromosome
Accession NZ_CP058548
Organism Klebsiella pneumoniae strain S165-1

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag HXT63_RS06890 Protein ID WP_020324801.1
Coordinates 1365097..1365438 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag HXT63_RS06895 Protein ID WP_020324792.1
Coordinates 1365459..1365776 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT63_RS06870 (1361398) 1361398..1363239 + 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
HXT63_RS06875 (1363339) 1363339..1363845 - 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
HXT63_RS06885 (1364148) 1364148..1364981 - 834 WP_020324805.1 DUF4942 domain-containing protein -
HXT63_RS06890 (1365097) 1365097..1365438 - 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
HXT63_RS06895 (1365459) 1365459..1365776 - 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HXT63_RS06900 (1365789) 1365789..1366016 - 228 WP_020324796.1 DUF987 domain-containing protein -
HXT63_RS06905 (1366025) 1366025..1366501 - 477 WP_020324797.1 RadC family protein -
HXT63_RS06910 (1366517) 1366517..1366975 - 459 WP_020324813.1 antirestriction protein -
HXT63_RS06915 (1367078) 1367078..1367317 - 240 WP_088183552.1 DUF905 domain-containing protein -
HXT63_RS06920 (1367410) 1367410..1370562 - 3153 WP_237086690.1 AIDA repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimG / fimF / fimD / fimC / fimI / fimA 1365097..1412745 47648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T166783 WP_020324801.1 NZ_CP058548:c1365438-1365097 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T166783 NZ_CP074437:1713278-1713625 [Klebsiella sp. A52]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGCAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGGTCCGCAGCTTGGGCGTCCGTATGTTGATACGGTAAAAGGTTCAAAGTTTCAGA
ATATGAAAGAACTTCGGGTTCAGCATCATGGGCTCCCAGTCCGCGCCTTTTTTGCTTTTGATCCTCTTCGGAAAGCTATC
GTTATATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACCCTGGCTGATAGAGAATT
CAGCCAGCACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT166783 WP_020324792.1 NZ_CP058548:c1365776-1365459 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT166783 NZ_CP074437:1713625-1713924 [Klebsiella sp. A52]
ATGGGCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGCGAAGAGTTACAAATTTCACAAACGGAGATGGCTGCGGCTATGGGGGTTAAGC
AGCCAACGATTGCTAAAATGGAACAGGCTGATAACGACCCGAGGCTTTCTACCCTAAAGCGCTACATTGCGGCCTTGGGT
GGGGAACTAAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References