Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
| Location | 1234227..1234884 | Replicon | chromosome |
| Accession | NZ_CP058548 | ||
| Organism | Klebsiella pneumoniae strain S165-1 | ||
Toxin (Protein)
| Gene name | cptA | Uniprot ID | - |
| Locus tag | HXT63_RS06210 | Protein ID | WP_040245400.1 |
| Coordinates | 1234227..1234637 (-) | Length | 137 a.a. |
Antitoxin (Protein)
| Gene name | cptB | Uniprot ID | W8UQ37 |
| Locus tag | HXT63_RS06215 | Protein ID | WP_002916312.1 |
| Coordinates | 1234618..1234884 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HXT63_RS06190 (1230227) | 1230227..1231960 | - | 1734 | WP_004149758.1 | single-stranded-DNA-specific exonuclease RecJ | - |
| HXT63_RS06195 (1231966) | 1231966..1232679 | - | 714 | WP_048290928.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
| HXT63_RS06200 (1232702) | 1232702..1233598 | - | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
| HXT63_RS06205 (1233699) | 1233699..1234220 | + | 522 | WP_002916308.1 | flavodoxin FldB | - |
| HXT63_RS06210 (1234227) | 1234227..1234637 | - | 411 | WP_040245400.1 | protein YgfX | Toxin |
| HXT63_RS06215 (1234618) | 1234618..1234884 | - | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
| HXT63_RS06220 (1235130) | 1235130..1236113 | + | 984 | WP_032430613.1 | tRNA-modifying protein YgfZ | - |
| HXT63_RS06225 (1236264) | 1236264..1236923 | - | 660 | WP_048334397.1 | hemolysin III family protein | - |
| HXT63_RS06230 (1237087) | 1237087..1237398 | - | 312 | WP_004144734.1 | N(4)-acetylcytidine aminohydrolase | - |
| HXT63_RS06235 (1237448) | 1237448..1238176 | + | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
| HXT63_RS06240 (1238295) | 1238295..1239728 | + | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16035.83 Da Isoelectric Point: 11.4778
>T166782 WP_040245400.1 NZ_CP058548:c1234637-1234227 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 411 bp
>T166782 NZ_CP074437:1440179-1440754 [Klebsiella sp. A52]
ATGCGACATTCACCTTATCCGGTGATTTTAGATGCTTGTGTATTATATCCAGCACGGCTCAGGGATTTATTAATGCACTT
AGGGATCGCTGGACTTTATCAACCAAAATGGAGCCGCTTCATTCACGATGAATGGTGCAGGAATCTCCTTATAAATCGGC
CCGATATAGCACCTGAAGCGCTGCGTCGTACCGTTGATCTCATGAATGCAGCTTTACCGGATGCTAATGTAACGGGTTTT
GCAGGATTAATTAACGGACTAGTTTTACCCGACCCTGACGATCGGCATGTCCTTGCTGCGGCAATCAGAGCGAAGGCTGA
AATTATCGTTACGTTAAATCATAAAGACTTTCCAGCAGAATCATTGCTTCCATTTGAAATTGAAACACTTCATCCTGATG
TTTTCATATCGGATCTGTTCGACCTAAATCATGCACTGGCGTTGGAAGCGGTGAGAAGGCAGCGGCAGTCTCTCAAGCAT
CCTCCAATGACCGTCGATGAGTTCCTGGAGATGCTGCTAAAGCAGGGCTTGCCGATGACGGTAAAAGAGTTAGCTAATTA
CCAGTACGCCATATAG
ATGCGACATTCACCTTATCCGGTGATTTTAGATGCTTGTGTATTATATCCAGCACGGCTCAGGGATTTATTAATGCACTT
AGGGATCGCTGGACTTTATCAACCAAAATGGAGCCGCTTCATTCACGATGAATGGTGCAGGAATCTCCTTATAAATCGGC
CCGATATAGCACCTGAAGCGCTGCGTCGTACCGTTGATCTCATGAATGCAGCTTTACCGGATGCTAATGTAACGGGTTTT
GCAGGATTAATTAACGGACTAGTTTTACCCGACCCTGACGATCGGCATGTCCTTGCTGCGGCAATCAGAGCGAAGGCTGA
AATTATCGTTACGTTAAATCATAAAGACTTTCCAGCAGAATCATTGCTTCCATTTGAAATTGAAACACTTCATCCTGATG
TTTTCATATCGGATCTGTTCGACCTAAATCATGCACTGGCGTTGGAAGCGGTGAGAAGGCAGCGGCAGTCTCTCAAGCAT
CCTCCAATGACCGTCGATGAGTTCCTGGAGATGCTGCTAAAGCAGGGCTTGCCGATGACGGTAAAAGAGTTAGCTAATTA
CCAGTACGCCATATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT166782 WP_002916312.1 NZ_CP058548:c1234884-1234618 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT166782 NZ_CP074437:1439733-1440179 [Klebsiella sp. A52]
ATGACTAAACTGAACCTTCCGGATCCGCAGGAGAGTGAACTTGCCCAGCGCGGGCAGCGTGAGCTGGCGGCATATCTTTC
TACTCATCTTGAAACGCAGCGTATTGCGATTGTGGGTGAAGATGACAAGACCCATACTATTGAGTTGCCAACCAGCGCTC
TGACTATGCTGATGGAGATCCTTGGGGAATTGGCTTGTGGCAACGCGGTGCAGATTGTTCCTGTTCATGCTGAACTCACC
ACCCAGGAAGCAGCGAATATCCTCAATGTTTCTCGTCCGCATATGGTTAAACTGCTGGAAGCGAGGAAGCTTCCATTTCA
TAAAACTGGACGCCATCGGCGGGTTCTGTTTGCCGATCTGATGGAGTATAAAAAACGTAGGGAACAGGAAAGCCTGGACG
CGATGCAAGCGCTGGCGGATCAGGCGCAGGACTTAGGGATGTATTAA
ATGACTAAACTGAACCTTCCGGATCCGCAGGAGAGTGAACTTGCCCAGCGCGGGCAGCGTGAGCTGGCGGCATATCTTTC
TACTCATCTTGAAACGCAGCGTATTGCGATTGTGGGTGAAGATGACAAGACCCATACTATTGAGTTGCCAACCAGCGCTC
TGACTATGCTGATGGAGATCCTTGGGGAATTGGCTTGTGGCAACGCGGTGCAGATTGTTCCTGTTCATGCTGAACTCACC
ACCCAGGAAGCAGCGAATATCCTCAATGTTTCTCGTCCGCATATGGTTAAACTGCTGGAAGCGAGGAAGCTTCCATTTCA
TAAAACTGGACGCCATCGGCGGGTTCTGTTTGCCGATCTGATGGAGTATAAAAAACGTAGGGAACAGGAAAGCCTGGACG
CGATGCAAGCGCTGGCGGATCAGGCGCAGGACTTAGGGATGTATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|