Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 6472..6997 Replicon plasmid pS161-2.1
Accession NZ_CP058545
Organism Klebsiella pneumoniae strain S161-2

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag HYH18_RS26150 Protein ID WP_013023785.1
Coordinates 6692..6997 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag HYH18_RS26145 Protein ID WP_001568025.1
Coordinates 6472..6690 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYH18_RS26120 1628..2407 + 780 WP_013023780.1 hypothetical protein -
HYH18_RS26125 2683..4206 + 1524 WP_017899887.1 hypothetical protein -
HYH18_RS26130 4240..5367 + 1128 WP_013023782.1 DUF4238 domain-containing protein -
HYH18_RS26135 5364..5654 + 291 WP_013023783.1 hypothetical protein -
HYH18_RS26140 5644..5841 - 198 WP_017899886.1 hypothetical protein -
HYH18_RS26145 6472..6690 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HYH18_RS26150 6692..6997 + 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
HYH18_RS26155 7166..7561 + 396 WP_017899885.1 hypothetical protein -
HYH18_RS26160 7588..7902 + 315 WP_053389906.1 hypothetical protein -
HYH18_RS26165 7913..8929 + 1017 WP_017899884.1 hypothetical protein -
HYH18_RS26170 9127..9921 + 795 WP_004197635.1 site-specific integrase -
HYH18_RS26175 10369..10671 - 303 WP_004197636.1 hypothetical protein -
HYH18_RS26180 10668..11294 - 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1C / blaCTX-M-15 / tet(A) - 1..104999 104999


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T166771 WP_013023785.1 NZ_CP058545:6692-6997 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T166771 NZ_CP074428:c3987805-3987518 [Salmonella sp. SJTUF14523]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT166771 WP_001568025.1 NZ_CP058545:6472-6690 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT166771 NZ_CP074428:c3987531-3987229 [Salmonella sp. SJTUF14523]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References