Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4659251..4659870 Replicon chromosome
Accession NZ_CP058544
Organism Klebsiella pneumoniae strain S161-2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HYH18_RS22905 Protein ID WP_002892050.1
Coordinates 4659652..4659870 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HYH18_RS22900 Protein ID WP_002892066.1
Coordinates 4659251..4659625 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYH18_RS22890 4654403..4655596 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HYH18_RS22895 4655619..4658765 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HYH18_RS22900 4659251..4659625 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HYH18_RS22905 4659652..4659870 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HYH18_RS22910 4660029..4660595 + 567 WP_002892030.1 maltose O-acetyltransferase -
HYH18_RS22915 4660567..4660707 - 141 WP_004147370.1 hypothetical protein -
HYH18_RS22920 4660728..4661198 + 471 WP_002892026.1 YlaC family protein -
HYH18_RS22925 4661173..4662624 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HYH18_RS22930 4662725..4663423 + 699 WP_094310543.1 GNAT family protein -
HYH18_RS22935 4663420..4663560 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HYH18_RS22940 4663560..4663823 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T166769 WP_002892050.1 NZ_CP058544:4659652-4659870 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T166769 NZ_CP074428:3412101-3412319 [Salmonella sp. SJTUF14523]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT166769 WP_002892066.1 NZ_CP058544:4659251-4659625 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT166769 NZ_CP074428:3411699-3412073 [Salmonella sp. SJTUF14523]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References