Detailed information of TA system TA166767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3276942..3278530
• Replicon: chromosome
• Accession: NZ_CP058544
• Organism: Klebsiella pneumoniae strain S161-2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HYH18_RS16240
• Protein ID: WP_040148030.1
• Coordinates: 3276942..3278264 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HYH18_RS16245
• Protein ID: WP_002904790.1
• Coordinates: 3278264..3278530 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYH18_RS16225	3271998..3274499	+	2502	WP_094310435.1	fimbria/pilus outer membrane usher protein	-
HYH18_RS16230	3274487..3275491	+	1005	WP_094310434.1	fimbrial protein	-
HYH18_RS16235	3275633..3276925	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HYH18_RS16240	3276942..3278264	-	1323	WP_040148030.1	type II toxin-antitoxin system HipA family toxin	Toxin
HYH18_RS16245	3278264..3278530	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HYH18_RS16250	3278795..3279121	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
HYH18_RS16255	3279118..3279618	-	501	WP_094310433.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HYH18_RS16260	3279596..3280975	-	1380	WP_237085143.1	nucleobase:cation symporter-2 family protein	-
HYH18_RS16265	3281321..3282475	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HYH18_RS16270	3282456..3283379	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49155.46 Da
• Isoelectric Point: 7.5366

>T166767 WP_040148030.1 NZ_CP058544:c3278264-3276942 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T166767 NZ_CP074428:c2444126-2443971 [Salmonella sp. SJTUF14523]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT166767 WP_002904790.1 NZ_CP058544:c3278530-3278264 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT166767 NZ_CP074428:2444138-2444196 [Salmonella sp. SJTUF14523]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8