Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1480747..1481404 Replicon chromosome
Accession NZ_CP058544
Organism Klebsiella pneumoniae strain S161-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HYH18_RS07220 Protein ID WP_002916310.1
Coordinates 1480994..1481404 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HYH18_RS07215 Protein ID WP_002916312.1
Coordinates 1480747..1481013 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYH18_RS07190 1475955..1477388 - 1434 WP_094310502.1 6-phospho-beta-glucosidase -
HYH18_RS07195 1477507..1478235 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HYH18_RS07200 1478285..1478596 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HYH18_RS07205 1478760..1479419 + 660 WP_002916317.1 hemolysin III family protein -
HYH18_RS07210 1479518..1480501 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HYH18_RS07215 1480747..1481013 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HYH18_RS07220 1480994..1481404 + 411 WP_002916310.1 protein YgfX Toxin
HYH18_RS07225 1481411..1481932 - 522 WP_040190094.1 flavodoxin FldB -
HYH18_RS07230 1482033..1482929 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HYH18_RS07235 1482952..1483665 + 714 WP_094310501.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HYH18_RS07240 1483671..1485404 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T166757 WP_002916310.1 NZ_CP058544:1480994-1481404 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T166757 NZ_CP074426:40902-41051 [Salmonella sp. SJTUF15034]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT166757 WP_002916312.1 NZ_CP058544:1480747-1481013 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166757 NZ_CP074426:c40857-40798 [Salmonella sp. SJTUF15034]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References