Detailed information of TA system TA166756

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1394537..1395314
• Replicon: chromosome
• Accession: NZ_CP058544
• Organism: Klebsiella pneumoniae strain S161-2

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HYH18_RS06760
• Protein ID: WP_237085266.1
• Coordinates: 1394537..1394914 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HYH18_RS06765
• Protein ID: WP_064155793.1
• Coordinates: 1394955..1395314 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYH18_RS06730	1390289..1391176	+	888	WP_223272580.1	EAL domain-containing protein	-
HYH18_RS06735	1391472..1391747	+	276	WP_023287993.1	EAL domain-containing protein	-
HYH18_RS06745	1391960..1392965	-	1006	Protein_1303	integrase arm-type DNA-binding domain-containing protein	-
HYH18_RS06750	1393723..1393920	-	198	Protein_1304	restriction endonuclease subunit M	-
HYH18_RS06755	1394049..1394540	-	492	WP_044349294.1	DUF5983 family protein	-
HYH18_RS06760	1394537..1394914	-	378	WP_237085266.1	TA system toxin CbtA family protein	Toxin
HYH18_RS06765	1394955..1395314	-	360	WP_064155793.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HYH18_RS06770	1395339..1395560	-	222	WP_004192297.1	DUF987 domain-containing protein	-
HYH18_RS06775	1395574..1396053	-	480	WP_044349286.1	DNA repair protein RadC	-
HYH18_RS06780	1396065..1396508	-	444	WP_044349284.1	antirestriction protein	-
HYH18_RS06785	1396588..1396818	-	231	WP_087776359.1	DUF905 domain-containing protein	-
HYH18_RS06790	1396842..1397666	-	825	WP_065805884.1	DUF932 domain-containing protein	-
HYH18_RS06795	1398207..1398839	+	633	WP_237085267.1	inovirus Gp2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	mrkA / mrkB / mrkC / mrkF / mrkJ	1382308..1419780	37472

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13939.86 Da
• Isoelectric Point: 6.6390

>T166756 WP_237085266.1 NZ_CP058544:c1394914-1394537 [Klebsiella pneumoniae]
MKILSDSPTRAAPSRPSPVEIWQTLLTYLLDQHYGLTLNDTPFGHDGMIQEHIDTGITLCDAVNLIVEKYKLVRIDRHGF
SADTQSPLIGSIDILRARKETGLMTRHGYRAITDITTGKYSEAGQ

Nucleotide

• Length: 378 bp

>T166756 NZ_CP074425:4489913-4490224 [Salmonella sp. SJTUF15034]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13369.23 Da
• Isoelectric Point: 7.0267

>AT166756 WP_064155793.1 NZ_CP058544:c1395314-1394955 [Klebsiella pneumoniae]
MSKKTTITTHDISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSHGYLYLAIYTTPATAA

Nucleotide

• Length: 360 bp

>AT166756 NZ_CP074425:4490221-4490667 [Salmonella sp. SJTUF15034]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG