Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 399770..400440 Replicon plasmid pAtEML4
Accession NZ_CP058527
Organism Agrobacterium tumefaciens strain EML4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EML4_RS25575 Protein ID WP_121593481.1
Coordinates 399770..400189 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A822VAD5
Locus tag EML4_RS25580 Protein ID WP_060726010.1
Coordinates 400186..400440 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EML4_RS25545 394999..395844 - 846 WP_121593482.1 transporter substrate-binding domain-containing protein -
EML4_RS25550 395884..396534 - 651 WP_060725904.1 amino acid ABC transporter permease -
EML4_RS25555 396544..397212 - 669 WP_060725903.1 amino acid ABC transporter permease -
EML4_RS25560 397223..397978 - 756 WP_174014749.1 amino acid ABC transporter ATP-binding protein -
EML4_RS25565 397997..398470 - 474 WP_060725902.1 RidA family protein -
EML4_RS25570 398928..399680 + 753 WP_060725901.1 FadR family transcriptional regulator -
EML4_RS25575 399770..400189 - 420 WP_121593481.1 type II toxin-antitoxin system VapC family toxin Toxin
EML4_RS25580 400186..400440 - 255 WP_060726010.1 hypothetical protein Antitoxin
EML4_RS25585 400735..401874 - 1140 WP_112960070.1 mandelate racemase/muconate lactonizing enzyme family protein -
EML4_RS25590 401888..402808 - 921 WP_112960071.1 dihydrodipicolinate synthase family protein -
EML4_RS25595 402810..403520 - 711 WP_112960072.1 GntR family transcriptional regulator -
EML4_RS25600 403636..405228 + 1593 WP_121593480.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..520191 520191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 20622.74 Da        Isoelectric Point: 5.5500

>T166748 WP_121593481.1 NZ_CP058527:c400189-399770 [Agrobacterium tumefaciens]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 420 bp

>T166748 NZ_CP074425:c2693042-2692939 [Salmonella sp. SJTUF15034]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 12528.03 Da        Isoelectric Point: 5.5500

>AT166748 WP_060726010.1 NZ_CP058527:c400440-400186 [Agrobacterium tumefaciens]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFF

Download         Length: 255 bp

>AT166748 NZ_CP074425:2692937-2693082 [Salmonella sp. SJTUF15034]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A822VAD5

References