Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 234685..235187 Replicon plasmid pIAE1
Accession NZ_CP058410
Organism Trichlorobacter lovleyi strain IAE

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FY034_RS18640 Protein ID WP_265552565.1
Coordinates 234685..234939 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FY034_RS18645 Protein ID WP_265555334.1
Coordinates 234936..235187 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY034_RS18615 (FY034_18635) 229815..230381 + 567 WP_265555395.1 guanylate kinase -
FY034_RS18620 (FY034_18640) 230385..230963 + 579 WP_265555398.1 nicotinate (nicotinamide) nucleotide adenylyltransferase -
FY034_RS18625 (FY034_18645) 230967..231983 - 1017 WP_265555400.1 FAD:protein FMN transferase -
FY034_RS18630 (FY034_18650) 232577..233914 - 1338 WP_224963446.1 transposase -
FY034_RS18635 (FY034_18655) 234146..234643 + 498 WP_265555332.1 alpha/beta hydrolase -
FY034_RS18640 (FY034_18660) 234685..234939 - 255 WP_265552565.1 Txe/YoeB family addiction module toxin Toxin
FY034_RS18645 (FY034_18665) 234936..235187 - 252 WP_265555334.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FY034_RS18650 (FY034_18670) 235313..236254 + 942 WP_265555403.1 adenosylcobinamide-phosphate synthase CbiB -
FY034_RS18655 (FY034_18675) 236514..237644 + 1131 WP_265555404.1 ATP-binding protein -
FY034_RS18660 (FY034_18680) 237811..238524 - 714 WP_265555406.1 NAD-dependent epimerase/dehydratase family protein -
FY034_RS18665 (FY034_18685) 238503..238862 - 360 Protein_272 GNAT family N-acetyltransferase -
FY034_RS18670 (FY034_18690) 238990..239829 - 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
FY034_RS18675 (FY034_18695) 239823..240170 - 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE - 1..289634 289634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9956.52 Da        Isoelectric Point: 8.4984

>T166746 WP_265552565.1 NZ_CP058410:c234939-234685 [Trichlorobacter lovleyi]
MMIKFSTAAWEDYLYWQTTDKAMLKRINQLIRDIQREPFAGIGKPEPLKHQLAGFWSRRIDSCHRLVYAVEGDTLLIAQC
RDHY

Download         Length: 255 bp

>T166746 NZ_CP074425:c988502-987975 [Salmonella sp. SJTUF15034]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9391.56 Da        Isoelectric Point: 5.5900

>AT166746 WP_265555334.1 NZ_CP058410:c235187-234936 [Trichlorobacter lovleyi]
MNALTYTYTRQHFAEVMKSVNEDHVPVVVTSQRGKPVVILSLDDFHAYEETAYLLRNPQGAKRLLESVEELRAGGGQTRD
LTE

Download         Length: 252 bp

>AT166746 NZ_CP074425:c988789-988499 [Salmonella sp. SJTUF15034]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References